Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors By similarity.Nusbaum C., Nature 439:331-335(2006).Bauer M., Biochim. Biophys. Acta 1354:183-188(1997).Just M., J. Biol. Chem. 266:17326-17332(1991).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human Collagen XIV α1.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors By similarity.
Nusbaum C., Nature 439:331-335(2006). Bauer M., Biochim. Biophys. Acta 1354:183-188(1997). Just M., J. Biol. Chem. 266:17326-17332(1991).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total Collagen XIV α1 protein.
Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity).
Protein Families
Fibril-associated collagens with interrupted helices (FACIT) family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.