O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan.Heinonen T.Y.K., Biochem. Biophys. Res. Commun. 309:166-174(2003).Sato T., Glycobiology 16:1194-1206(2006).Dunham A., Nature 428:522-528(2004).
Host
Rabbit
Immunogen
Synthesized peptide derived from C-terminal of Human B3GALTL.
Involvement In Disease
Peters-plus syndrome (PPLS)
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan.
Heinonen T.Y.K., Biochem. Biophys. Res. Commun. 309:166-174(2003). Sato T., Glycobiology 16:1194-1206(2006). Dunham A., Nature 428:522-528(2004).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total B3GALTL protein.
Subcellular Location
Endoplasmic reticulum membrane, Single-pass type II membrane protein
O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan.
Protein Families
Glycosyltransferase 31 family
Tissue Specificity
Widely expressed, with highest levels in testis and uterus.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.