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Home / Primary Antibodies / IHC Antibodies

APAF1 Antibody

SKU : BHA10559166

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA109273
Alternative Names	APAF1-interacting protein; APIP; APIP2; CGI-29 protein; MMRP19
Categories	Primary Antibodies
Clonality	polyclonal
Description	This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.Keigo Machida, J. Biol. Chem., Apr 2001; 276: 12140 - 12146.Liam O 鐤宱nnor, Cancer Res., Mar 2000; 60: 1217 - 1220.Zeping Wang, Nucleic Acids Res., Apr 2005; 33: 2248 - 2258Govindaraj Anumanthan, Cancer Res., Nov 2006; 66: 10824 - 10832.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human APAF-1-ALT.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. Keigo Machida, J. Biol. Chem., Apr 2001; 276: 12140 - 12146. Liam O?nnor, Cancer Res., Mar 2000; 60: 1217 - 1220. Zeping Wang, Nucleic Acids Res., Apr 2005; 33: 2248 - 2258 Govindaraj Anumanthan, Cancer Res., Nov 2006; 66: 10824 - 10832.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total APAF-1-ALT protein.

Uniprot	O14727-6
Gene Id	317
Weight	37,976 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:3000
IHC	1:50-1:200
IF	1:100-1:200

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:200,IF:1:100-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559166	CSB-PA109273	100ul	$297		Add to Cart

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