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Home / Proteins & Peptide

FKBP12, His-tag

SKU : BHP18200270

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BPS Bioscience

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Mfr.No.	40550
Description	Human FKBP12 (FK506 binding protein 1A, transcript variant 12A), GenBank Accession No. NM_054014, full length with N-terminal His-tag, MW= 13.1 kDa, expressed in an E. coli expression system. 5References: 1. Knappe,T.A. et al., J. Mol. Biol. 368 (5), 1458-1468 (2007). 2. Wear,M.A. et al., Protein Expr. Purif. 51 (1), 80-95 (2007).
Background	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity.
Immunogen Region	full length
Tag	N-terminal His-tag
Formulation	50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 50% glycerol.
Species	Human
Application	Useful for testing rapamycin inhibition of mTOR.
Notes	Avoid freeze/thaw cycles.
GenBank	NM_054014
Mw(kda)	13.1 kDa

Synonyms	FK506 Binding Protein 1, FKBP, Rotamase, Immunophilin FKBP12, PPIase, Calstabin
Uniprot	P62942

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	Store at -80°C. Stable for>6 months when stored as directed.

Reference	1. Knappe,T.A. et al., J. Mol. Biol. 368 (5),1458-1468 (2007). 2. Wear,M.A. et al., Protein Expr. Purif. 51 (1),80-95 (2007).Application Reference:Structure of glutaraldehyde cross-linked ryanodine receptor (2013)

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200270	40550	200 ug	$456.50		Add to Cart

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