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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat TGF-beta receptor type-1

SKU : BHE13810690

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E8813r
Alternative Names	Serine/threonine-protein kinase receptor R4 ; SKR4 ; TGF-beta type I receptor ; Transforming growth factor-beta receptor type I ; TGF-beta receptor type I
Categories	Elisa
Function	Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PAR6A phosphorylation and activation.
Specificity	Natural and recombinant Rat TGF-beta receptor type-1
Subcellular Location	Cell membrane Single-pass type I membrane protein Cell junction tight junction
Detection Range	0.312-20ng/mL
Entryname	TGFR1_RAT
Method Type	Sandwich
Platform	PF01064
Protein Name	TGF-beta receptor type-1
Sensitivity	0.178ng/mL
Sequence	50: MEAASAALRR ; CLLLIVLVAA ; ATLLPGAKAL ; QCFCHLCTKD ; NFTCETDGLC ; 100: FVSVTETTDK ; VIHNSMCIAE ; IDLIPRDRPF ; VCAPSSKTGA ; VTYCCNQDHC ; 150: NKIELPTTGP ; FSEKQSAGLG ; PVELAAVIAG ; PVCFVCIALM ; LMVYICHNRT ; 200: VIHHRVPNEE ; DPSLDRPFIS ; EGTTLKDLIY ; DMTTSGSGSG ; LPLLVQRTIA ; 250: RTIVLQESIG ; KGRFGEVWRG ; KWRGEEVAVK ; IFSSREERSW ; FREAEIYQTV ; 300: MLRHENILGF ; IAADNKDNGT ; WTQLWLVSDY ; HEHGSLFDYL ; NRYTVTVEGM ; 350: IKLALSTASG ; LAHLHMEIVG ; TQGKPAIAHR ; DLKSKNILVK ; KNGTCCIADL ; 400: GLAVRHDSAT ; DTIDIAPNHR ; VGTKRYMAPE ; VLDDSINMKH ; FESFKRADIY ; 450: AMGLVFWEIA ; RRCSIGGIHE ; DYQLPYYDLV ; PSDPSVEEMR ; KVVCEQKLRP ; 500: NIPNRWQSCE ; ALRVMAKIMR ; ECWYANGAAR ; LTALRIKKTL ; SQLSQQEGIK ; 501: M
Sequence Length	501
String	P80204
Sub Unit	Homodimer; in the endoplasmic reticulum but also at the cell membrane. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGBRB1 and TGFBR2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Interacts with CD109; inhibits TGF-beta receptor activation in keratinocytes. Interacts with RBPMS. Interacts with SMAD2, SMAD3 and ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor. Interacts with TRAF6 and MAP3K7; induces MAP3K7 activation by TRAF6. Interacts with PAR6A; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with SMAD7, NEDD4L, SMURF1 and SMURF2; SMAD7 recruits NEDD4L, SMURF1 and SMURF2 to the TGF-beta receptor (By similarity). Interacts (unphosphorylated) with FKBP1A; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation.

Uniprot	P80204
Gene Name	Tgfbr1
Immunogen Species	Rattus norvegicus (Rat)
Unigene	Rn.44402

Reference	1. "Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family." He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K. Dev. Dyn.196:133-142(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Urogenital ridge. 2. "The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors." Wang T., Li B.Y., Danielson P.D., Shah P.C., Rockwell S., Lechleider R.J., Martin J., Manganaro T., Donahoe P.K. Cell86:435-444(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FKBP1A;ENZYME REGULATION 3. "The type I TGF-beta receptor is covalently modified and regulated by sumoylation." Kang J.S., Saunier E.F., Akhurst R.J., Derynck R. Nat. Cell Biol.10:654-664(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-389

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810690	E8813r	96T	$796		Add to Cart

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