Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
Specificity
Natural and recombinant Rat Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Subcellular Location
Secreted Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);PROTEIN SEQUENCE OF 28-32 AND 36-41;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;SUBCELLULAR LOCATION;MUTAGENESIS OF ASP-171; THR-209; ASP-311 AND HIS-315
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;PROTEIN SEQUENCE OF N-TERMINUS;FUNCTION CHARACTERIZATION;SUBCELLULAR LOCATION;MUTAGENESIS OF ILE-13; 16-PHE--PHE-18; 18-PHE--SER-21; 21-SER--ILE-24; 24-ILE--CYS-25 AND 28-PHE--ALA-30
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 36-862 IN COMPLEX WITH INHIBITOR AND ZINC IONS;CATALYTIC ACTIVITY;COFACTOR;CALCIUM BINDING;DISULFIDE BONDS;GLYCOSYLATION AT ASN-524;ACTIVE SITE;MUTAGENESIS OF LYS-430 AND 764-ASP--ASP-768;SUBCELLULAR LOCATION
Reviews of ELISA Kit for Rat Ectonucleotide pyrophosphatase/phosphodiesterase family member 2