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ELISA Kit for Mouse Vang-like protein 2

SKU : BHE13811915

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15196m
Alternative Names	Loop-tail protein 1 ; Loop-tail-associated protein ; Van Gogh-like protein 2 ; Lpp1 ; Ltap
Categories	Elisa
Function	Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process.
Specificity	Natural and recombinant Mouse Vang-like protein 2
Subcellular Location	Membrane Multi-pass membrane protein
Entryname	VANG2_MOUSE
Platform	PF06638
Protein Name	Vang-like protein 2
Sequence	50: MDTESQYSGY ; SYKSGHSRSS ; RKHRDRRDRH ; RSKSRDGSRG ; DKSVTIQAPG ; 100: EPLLDNESTR ; GDERDDNWGE ; TTTVVTGTSE ; HSISHDDLTR ; IAKDMEDSVP ; 150: LDCSRHLGVA ; AGAILALLSF ; LTPLAFLLLP ; PLLWREELEP ; CGTACEGLFI ; 200: SVAFKLLILL ; LGSWALFFRR ; PKASLPRVFV ; LRALLMVLVF ; LLVISYWLFY ; 250: GVRILDARER ; SYQGVVQFAV ; SLVDALLFVH ; YLAVVLLELR ; QLQPQFTLKV ; 300: VRSTDGASRF ; YNVGHLSIQR ; VAVWILEKYY ; HDFPVYNPAL ; LNLPKSVLAK ; 350: KVSGFKVYSL ; GEENSTNNST ; GQSRAVIAAA ; ARRRDNSHNE ; YYYEEAEHER ; 400: RVRKRRARLV ; VAVEEAFTHI ; KRLQEEEQKN ; PREVMDPREA ; AQAIFASMAR ; 450: AMQKYLRTTK ; QQPYHTMESI ; LQHLEFCITH ; DMTPKAFLER ; YLAAGPTIQY ; 500: HKERWLAKQW ; TLVSEEPVTN ; GLKDGIVFLL ; KRQDFSLVVS ; TKKVPFFKLS ; 521: EEFVDPKSHK ; FVMRLQSETS ; V
Sequence Length	521
String	Q91ZD4
Sub Unit	Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Variants Glu-255 and Asn-464 impair interaction with the DVL proteins. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3.

Uniprot	Q91ZD4
Gene Name	Vangl2
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:93840
Unigene	Mm.36148

Reference	1. "Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification." Murdoch J.N., Doudney K., Paternotte C., Copp A.J., Stanier P. Hum. Mol. Genet.10:2593-2601(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;VARIANT LP ASN-464 strain: C57BL/6. 2. "Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant loop-tail." Kibar Z., Vogan K.J., Groulx N., Justice M.J., Underhill D.A., Gros P. Nat. Genet.28:251-255(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DEVELOPMENTAL STAGE;TISSUE SPECIFICITY;VARIANTS LP GLU-255 AND ASN-464 strain: C57BL/6J. 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Limb. 4. "Cardiovascular defects associated with abnormalities in midline development in the loop-tail mouse mutant." Henderson D.J., Conway S.J., Greene N.D.E., Gerrelli D., Murdoch J.N., Anderson R.H., Copp A.J. Circ. Res.89:6-12(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE 5. "Identification of Vangl2 and Scrb1 as planar polarity genes in mammals." Montcouquiol M., Rachel R.A., Lanford P.J., Copeland N.G., Jenkins N.A., Kelley M.W. Nature423:173-177(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE;TISSUE SPECIFICITY 6. "Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family." Torban E., Wang H.-J., Groulx N., Gros P. J. Biol. Chem.279:52703-52713(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DVL1; DVL2 AND DVL3 7. "MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap." Yao R., Natsume Y., Noda T. Oncogene23:6023-6030(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAGI3 8. "Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract." Phillips H.M., Murdoch J.N., Chaudhry B., Copp A.J., Henderson D.J. Circ. Res.96:292-299(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE 9. "The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells." Wang Y., Guo N., Nathans J. J. Neurosci.26:2147-2156(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 10. "Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals." Montcouquiol M., Sans N., Huss D., Kach J., Dickman J.D., Forge A., Rachel R.A., Copeland N.G., Jenkins N.A., Bogani D., Murdoch J., Warchol M.E., Wenthold R.J., Kelley M.W. J. Neurosci.26:5265-5275(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FZD3 AND SCRIB;TISSUE SPECIFICITY 11. "Molecular characterisation of endogenous Vangl2/Vangl1 heteromeric protein complexes." Belotti E., Puvirajesinghe T.M., Audebert S., Baudelet E., Camoin L., Pierres M., Lasvaux L., Ferracci G., Montcouquiol M., Borg J.P. PLoS ONE7:E46213-E46213(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;SUBUNIT

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