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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Serine/arginine-rich splicing factor 1

SKU : BHE13810880

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E8282m
Alternative Names	ASF/SF2 ; Pre-mRNA-splicing factor SRp30a ; Splicing factor ; arginine/serine-rich 1 ; Sfrs1
Categories	Elisa
Function	Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing (By similarity). Specifically regulates alternative splicing of cardiac isoforms of CAMK2D, LDB3/CYPHER and TNNT2/CTNT during heart remodeling at the juvenile to adult transition. The inappropriate accumulation of a neonatal and neuronal isoform of CAMKD2 in the adult heart results in aberrant calcium handling and defective excitation-contraction coupling in cardiomyocytes.
Specificity	Natural and recombinant Mouse Serine/arginine-rich splicing factor 1
Subcellular Location	Cytoplasm Nucleus Nucleus speckle Shuttles between the nucleus and the cytoplasm.
Detection Range	78-5000pg/ml
Entryname	SRSF1_MOUSE
Method Type	Sandwich
Platform	PF00076
Protein Name	Serine/arginine-rich splicing factor 1
Sensitivity	42.61pg/mL
Sequence	50: MSGGGVIRGP ; AGNNDCRIYV ; GNLPPDIRTK ; DIEDVFYKYG ; AIRDIDLKNR ; 100: RGGPPFAFVE ; FEDPRDAEDA ; VYGRDGYDYD ; GYRLRVEFPR ; SGRGTGRGGG ; 150: GGGGGGAPRG ; RYGPPSRRSE ; NRVVVSGLPP ; SGSWQDLKDH ; MREAGDVCYA ; 200: DVYRDGTGVV ; EFVRKEDMTY ; AVRKLDNTKF ; RSHEGETAYI ; RVKVDGPRSP ; 248: SYGRSRSRSR ; SRSRSRSRSN ; SRSRSYSPRR ; SRGSPRYSPR ; HSRSRSRT
Sequence Length	248
String	Q6PDM2
Sub Unit	Consists of two polypeptides of p32 and p33. In vitro, self-associates and binds SRSF2, SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with SAFB/SAFB1. Interacts with SRPK1. Interacts with PSIP1/LEDGF. Identified in the spliceosome C complex. Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus).

Uniprot	Q6PDM2
Gene Name	Srsf1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:110809
Unigene	Mm.391719

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810880	E8282m	96T	$776		Add to Cart

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