C-terminal PDZ ligand of neuronal nitric oxide synthase protein ; Nitric oxide synthase 1 adaptor protein ; Capon ; Kiaa0464
Categories
Elisa
Function
Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4.
Specificity
Natural and recombinant Mouse Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
Interacts with the PDZ domain of NOS1 or the second PDZ domain of DLG4 through its C-terminus. Interacts with RASD1 and SYN1, SYN2 and SYN3 via its PID domain. Forms a ternary complex with NOS1 and SYN1 (By similarity). Forms a ternary complex with NOS1 and RASD1.