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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Serine/threonine-protein kinase STK11

SKU : BHE13811516

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E13097h
Alternative Names	Liver kinase B1 ; LKB1 ; Renal carcinoma antigen NY-REN-19 ; LKB1 ; PJS
Categories	Elisa
Function	Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2: it thereby regulates inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neurons polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate to transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by dowstream STK11/LKB1 kinase NUAK1 Also acts as a mediator p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways.
Specificity	Natural and recombinant Human Serine/threonine-protein kinase STK11
Subcellular Location	Nucleus Cytoplasm Membrane Mitochondrion A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to mitochondrion during apoptosis.
Detection Range	0.156-10ng/mL
Entryname	STK11_HUMAN
Method Type	Sandwich
Platform	PF00069
Protein Name	Serine/threonine-protein kinase STK11
Sensitivity	0.078ng/mL
Sequence	50: MEVVDPQQLG ; MFTEGELMSV ; GMDTFIHRID ; STEVIYQPRR ; KRAKLIGKYL ; 100: MGDLLGEGSY ; GKVKEVLDSE ; TLCRRAVKIL ; KKKKLRRIPN ; GEANVKKEIQ ; 150: LLRRLRHKNV ; IQLVDVLYNE ; EKQKMYMVME ; YCVCGMQEML ; DSVPEKRFPV ; 200: CQAHGYFCQL ; IDGLEYLHSQ ; GIVHKDIKPG ; NLLLTTGGTL ; KISDLGVAEA ; 250: LHPFAADDTC ; RTSQGSPAFQ ; PPEIANGLDT ; FSGFKVDIWS ; AGVTLYNITT ; 300: GLYPFEGDNI ; YKLFENIGKG ; SYAIPGDCGP ; PLSDLLKGML ; EYEPAKRFSI ; 350: RQIRQHSWFR ; KKHPPAEAPV ; PIPPSPDTKD ; RWRSMTVVPY ; LEDLHGADED ; 400: EDLFDIEDDI ; IYTQDFTVPG ; QVPEEEASHN ; GQRRGLPKAV ; CMNGTEAAQL ; 433: STKSRAEGRA ; PNPARKACSA ; SSKIRRLSAC ; KQQ
Sequence Length	433
String	Q15831
Sub Unit	Catalytic component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Found in a ternary complex composed of SMAD4, STK11/LKB1 and STK11IP. Interacts with p53/TP53, SMAD4, STK11IP and WDR6.

Uniprot	Q15831
Gene Name	STK11
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6794
Unigene	Hs.515005

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811516	E13097h	96T	$736		Add to Cart

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