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ELISA Kit for Human Mothers against decapentaplegic homolog 4

SKU : BHE13810756

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1925h
Alternative Names	Deletion target in pancreatic carcinoma 4 ; SMAD family member 4 ; SMAD 4 ; DPC4 ; MADH4
Categories	Elisa
Function	Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor.
Specificity	Natural and recombinant Human Mothers against decapentaplegic homolog 4
Subcellular Location	Cytoplasm Nucleus Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R-SMAD.
Detection Range	15.6-1000pg/mL
Entryname	SMAD4_HUMAN
Method Type	Sandwich
Platform	PF03165
Protein Name	Mothers against decapentaplegic homolog 4
Sensitivity	8.08pg/mL
Sequence	50: MDNMSITNTP ; TSNDACLSIV ; HSLMCHRQGG ; ESETFAKRAI ; ESLVKKLKEK ; 100: KDELDSLITA ; ITTNGAHPSK ; CVTIQRTLDG ; RLQVAGRKGF ; PHVIYARLWR ; 150: WPDLHKNELK ; HVKYCQYAFD ; LKCDSVCVNP ; YHYERVVSPG ; IDLSGLTLQS ; 200: NAPSSMMVKD ; EYVHDFEGQP ; SLSTEGHSIQ ; TIQHPPSNRA ; STETYSTPAL ; 250: LAPSESNATS ; TANFPNIPVA ; STSQPASILG ; GSHSEGLLQI ; ASGPQPGQQQ ; 300: NGFTGQPATY ; HHNSTTTWTG ; SRTAPYTPNL ; PHHQNGHLQH ; HPPMPPHPGH ; 350: YWPVHNELAF ; QPPISNHPAP ; EYWCSIAYFE ; MDVQVGETFK ; VPSSCPIVTV ; 400: DGYVDPSGGD ; RFCLGQLSNV ; HRTEAIERAR ; LHIGKGVQLE ; CKGEGDVWVR ; 450: CLSDHAVFVQ ; SYYLDREAGR ; APGDAVHKIY ; PSAYIKVFDL ; RQCHRQMQQQ ; 500: AATAQAAAAA ; QAAAVAGNIP ; GPGSVGGIAP ; AISLSAAAGI ; GVDDLRRLCI ; 550: LRMSFVKGWG ; PDYPRQSIKE ; TPCWIEIHLH ; RALQLLDEVL ; HTMPIADPQP ; 552: LD
Sequence Length	552
String	Q13485
Sub Unit	Interacts with CITED2 (By similarity). Monomer; in the absence of TGF-beta activation. Heterodimer; on TGF-beta activation. Composed of two molecules of a C-terminally phosphorylated R-SMAD molecule, SMAD2 or SMAD3, and one molecule of SMAD4 to form the transcriptional active SMAD2/SMAD3-SMAD4 complex. Found in a ternary complex composed of SMAD4, STK11/LKB1 and STK11IP. Interacts with ATF2, COPS5, DACH1, MSG1, SKI, STK11/LKB1, STK11IP and TRIM33. Interacts with ZNF423; the interaction takes place in response to BMP2 leading to activation of transcription of BMP target genes. Interacts with ZNF521; the interaction takes place in response to BMP2 leading to activation of transcription of BMP target genes. Interacts with USP9X. Interacts (via the MH1 and MH2 domains) with RBPMS. Interacts with WWTR1 (via coiled-coil domain). Component of the multimeric complex SMAD3/SMAD4/JUN/FOS which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. Interacts with CITED1.

Uniprot	Q13485
Gene Name	SMAD4
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:4089
Unigene	Hs.75862

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810756	E1925h	96T	$736		Add to Cart

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