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ELISA Kit for Mouse NLR family CARD domain-containing protein 4

SKU : BHE13808176

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1535m
Alternative Names	Caspase recruitment domain-containing protein 12 ; Ice protease-activating factor ; Ipaf ; Card12 ; Ipaf
Categories	Elisa
Function	Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. It senses pathogenic proteins of the type III secretion system (T3SS) and type IV secretion system (T4SS) such as flagellin and PrgJ-like rod proteins via the Naip proteins (Naip1, Naip2 or Naip5): specific Naip proteins recognize and bind pathogenic proteins, driving assembly and activation of the NLRC4 inflammasome. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri and fungal pathogen C.albicans. In intestine, the NLRC4 inflammasome is able to discriminate between commensal and pathogenic bacteria and specifically drives production of interleukin-1 beta (IL1B) in response to infection by Salmonella or P.aeruginosa. In case of L.pneumophila infection the inflammasome acts by activating caspase-7.
Specificity	Natural and recombinant Mouse NLR family CARD domain-containing protein 4
Subcellular Location	Cytoplasm Cytosol
Detection Range	0.156-10ng/ml
Entryname	NLRC4_MOUSE
Method Type	Sandwich
Platform	PF00619
Protein Name	NLR family CARD domain-containing protein 4
Sensitivity	0.083ng/mL
Sequence	50: MNFIRNNRRA ; LIQRMGLTVT ; KQICDDLFAL ; NVLNNQEANV ; IYCEPLEQEA ; 100: ARKIIHMTMQ ; KGSAACNLFL ; KSLENWDYFV ; YQDLTGQNLS ; YQVTEEDLNV ; 150: LAQNLKDLYN ; SPAFLNFYPL ; GEDIDIIFNL ; EKTFTEPIMW ; KKDHRHHRVE ; 200: QLTLGSLLEA ; LKSPCLIEGE ; SGKGKSTLLQ ; RIAMLWASGG ; CRALKGFRLV ; 250: FFIHLRSARG ; GLFETLYDQL ; LNIPDFISKP ; TFKALLLKLH ; KEVLFLLDGY ; 300: NEFHPQNCPE ; IEALIKENHR ; FKNMVIVTTT ; TECLRHIRHV ; GALTAEVGDM ; 350: TEDSAKDLIE ; AVLVPDQVER ; LWAQIQESRC ; LRNLMKTPLF ; VVITCAIQMG ; 400: RQEFQAHTQT ; MLFQTFYDLL ; IQKNSHRYRG ; GASGDFARSL ; DYCGDLALEG ; 450: VFAHKFDFEP ; EHGSSMNEDV ; LVTIGLLCKY ; TAQRLKPTYK ; FFHKSFQEYT ; 500: AGRRLSSLLT ; SKEPEEVSKG ; NSYLNKMVSI ; SDITSLYGNL ; LLYTCGSSTE ; 550: ATRAVMRHLA ; MVYQHGSLQG ; LSVTKRPLWR ; QESIQSLRNT ; TEQDVLKAIN ; 600: VNSFVECGIN ; LFSESMSKSD ; LSQEFEAFFQ ; GKSLYINSEN ; IPDYLFDFFE ; 650: YLPNCASALD ; FVKLDFYERA ; TESQDKAEEN ; VPGVHTEGPS ; ETYIPPRAVS ; 700: LFFNWKQEFK ; TLEVTLRDIN ; KLNKQDIKYL ; GKIFSSATNL ; RLHIKRCAAM ; 750: AGRLSSVLRT ; CKNMHTLMVE ; ASPLTTDDEQ ; YITSVTGLQN ; LSIHRLHTQQ ; 800: LPGGLIDSLG ; NLKNLERLIL ; DDIRMNEEDA ; KNLAEGLRSL ; KKMRLLHLTH ; 850: LSDIGEGMDY ; IVKSLSEESC ; DLQEMKLVAC ; CLTANSVKVL ; AQNLHNLIKL ; 900: SILDISENYL ; EKDGNEALQE ; LIGRLGVLGE ; LTTLMLPWCW ; DVHTSLPKLL ; 950: KQLEGTPGLA ; KLGLKNWRLR ; DEEIKSLGEF ; LEMNPLRDLQ ; QLDLAGHCVS ; 1000: SDGWLYFMNV ; FENLKQLVFF ; DFSTEEFLPD ; AALVRKLSQV ; LSKLTLLQEV ; 1024: KLTGWEFDDY ; DISAIKGTFK ; LVTA
Sequence Length	1024
Sub Unit	Homooligomer; homooligomerizes following activation of Naip proteins by pathogenic proteins such as S.typhimurium (Salmonella) flagellin or PrgJ. Component of the NLRC4 inflammasome, at least composed of NLRC4, caspase-1 (CASP1) and some NAIP protein (Naip, Naip2 or Naip5). Interacts with Naip5 and Naip6; following Naip5 and Naip6 engagement by Salmonella flagellin. Interacts with Naip2; following Naip2 engagement by Salmonella PrgJ. Interacts with EIF2AK2/PKR.

Uniprot	Q3UP24
Gene Name	Nlrc4
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:268973
Unigene	Mm.311884

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808176	E1535m	96T	$776		Add to Cart

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