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Home / Assay Kits / ELISA Kits

ELISA Kit for Chicken V(D)J recombination-activating protein 2

SKU : BHE13808952

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1551c
Categories	Elisa
Function	Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3.
Specificity	Natural and recombinant Chicken V(D)J recombination-activating protein 2
Subcellular Location	Nucleus
Detection Range	0.78-50ng/ml
Entryname	RAG2_CHICK
Method Type	Sandwich
Platform	PF03089
Protein Name	V(D)J recombination-activating protein 2
Sensitivity	0.24ng/ml
Sequence	50: MSLQMVSAVS ; NSSLLQPGSS ; LLNFDGHVFF ; FGQKGWPKRS ; CPTGVFFLDI ; 100: KQNELKMKPA ; AFSRDSCYLP ; PLRYPAICTL ; RGNGESDKHQ ; YIIHGGKTPN ; 150: NDLSDKIYIM ; SMVNKTTKKT ; TFQCIEKDLG ; GDVPEARYGH ; TINVVHSRGK ; 200: SMIVIFGGRS ; YIPLAQRTTE ; KWNSVVDCLP ; SVFLVDFEFG ; CCTSYILPEL ; 250: QDGLSFHVSV ; ARDDTIYILG ; GHSLQNNTRP ; PSLYKLKVDL ; PLGSPCVTCS ; 300: ILPGGISVSS ; GIVTQTGDTE ; FVLVGGYQSD ; NQKRMICNTI ; VLEDNKIEIV ; 350: ERVSPDWTPD ; IKHCRMWFGC ; DMGKGSVLLG ; IPGANKQLIS ; DANYFYILRC ; 400: NKAEEDEEEE ; LTAQTCSQAS ; TEDQGDSTPF ; EDSEEFSFSA ; EASSFDVDDI ; 450: DTYNEDDEED ; ESETGYWIIC ; CASCNIDINT ; WVPFYSTELN ; KPAMILCSSG ; 500: SGHWVHAQCM ; DLSESMLLQL ; SEANVKYFCN ; EHVHLNKGLQ ; TPKKAVHLKK ; 528: QPMKRLHKKK ; TMKLTTPVKK ; SFLRRLFE
Sequence Length	528
String	P25022
Sub Unit	Component of the RAG complex composed of core components RAG1 and RAG2.

Uniprot	P25022
Gene Name	RAG2
Immunogen Species	Gallus Gallus (Chicken)
Unigene	Gga.23148

Reference	1. "Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion." Carlson L.M., Oettinger M.A., Schatz D.G., Masteller E.L., Hurley E.A., McCormack W.I., Baltimore D., Thompson C.B. Cell64:201-208(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808952	E1551c	96T	$900		Add to Cart

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