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Home / Primary Antibodies / Conjugated Primary Antibodies

NOD2 Antibody, FITC conjugated

SKU : BHA10526490

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA881021LC01HU
Alternative Names	Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1), NOD2, CARD15 IBD1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).
Host	Rabbit
Immunogen	Recombinant Human Nucleotide-binding oligomerization domain-containing protein 2 protein (460-733AA)
Involvement In Disease	Blau syndrome (BLAUS); Inflammatory bowel disease 1 (IBD1); Yao syndrome (YAOS)
Isotype	IgG
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).
Species	Homo Sapiens (Human)
Subcellular Location	Cytoplasm, Membrane, Basolateral cell membrane

Uniprot	Q9HC29
Database Links	HGNC:5331 OMIM:186580 KEGG:hsa:64127 STRING:9606.ENSP00000300589 UniGene:Hs.592072
Function	Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages
Pathway	TNF signaling pathway NOD-like receptor signaling pathway
Research Area	Cell Biology
Tissue Specificity	Expressed in intestinal mucosa, mainly in Paneth cells and, at lower extent, in the glandular epithelium.

Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form	Liquid
Format	Liquid
Purification	>95%, Protein G purified
Purity	>95%,Protein G purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Applications	ELISA
Description	ELISA
Tested Application	ELISA

Datasheet
ELISA Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10526490	CSB-PA881021LC01HU	100ug	$299		Add to Cart
BHA10526490	CSB-PA881021LC01HU	50ug	$166		Add to Cart

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