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Humanized Knockins

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

  • hIL1RAP

    hIL1RAP

    • Strain : Repository Live
    • KI/KO Gene : Il1rap
    • Research Application : Cytokine Humani
    • Nomenclature : C57BL/6Smoc-Il1
    • Description : The endogenous
  • hCCR8(2)/hTIGIT

    hCCR8(2)/hTIGIT

    • Strain : Repository Live
    • KI/KO Gene : CCR8
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Tig
    • Description : hTIGIT(NM-HU-20
  • hCCR8

    hCCR8

    • Strain : Embryo cryopres
    • KI/KO Gene : CCR8
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Ccr
    • Description : The endogenous
  • hCCR4(3)

    hCCR4(3)

    • Strain : Embryo cryopres
    • KI/KO Gene : Klf1
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Ccr
    • Description : The endogenous
  • hCD226

    hCD226

    • Strain : Repository Live
    • KI/KO Gene : Cd226
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Cd2
    • Description : The endogenous
  • hCD20

    hCD20

    • Strain : Embryo cryopres
    • KI/KO Gene : Ms4a1
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Ms4
    • Description : The endogenous
  • hCD27(2)/hFCGR2B

    hCD27(2)/hFCGR2B

    • Strain : Repository Live
    • KI/KO Gene : Fcgr2b
    • Nomenclature : C57BL/6Smoc-Cd2
    • Research Application : Immunotherapy
    • Description : hCD27(2) (NM-HU
  • hCD24/hSIGLEC10

    hCD24/hSIGLEC10

    • Strain : Embryo cryopres
    • KI/KO Gene : Siglecg
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Cd2
    • Description : hCD24(NM-HU-200
  • hCD3E/hPD-L1

    hCD3E/hPD-L1

    • Strain : Embryo cryopres
    • KI/KO Gene : CD3E
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Cd3
    • Description : hCD3E(NM-HU-001
  • hCD3E/hCD38(2)

    hCD3E/hCD38(2)

    • Strain : Embryo cryopres
    • KI/KO Gene : CD3E
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Cd3
    • Description : hCD3E(NM-HU-001
  • hCD3EDG/hCD28

    hCD3EDG/hCD28

    • Strain : Repository Live
    • KI/KO Gene : CD28
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Cd3
    • Description : hCD3EDG(NM-HU-2
  • hCD3EDG/hCD47

    hCD3EDG/hCD47

    • Strain : Repository Live
    • KI/KO Gene : CD3E
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Cd3
    • Description : hCD3EDG(NM-HU-2
  • hCD52

    hCD52

    • Strain : Repository Live
    • KI/KO Gene : Cd52
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Cd5
    • Description : The endogenous
  • hCEACAM5-Tg

    hCEACAM5-Tg

    • Strain : Sperm cryoprese
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Tg(
    • Description : These transgeni
    • Synonyms : CEA,CD66e
  • hCD81

    hCD81

    • Strain : Embryo cryopres
    • KI/KO Gene : CD81
    • Research Application : Hdv Infection R
    • Nomenclature : C57BL/6Smoc-Cd8
    • Description : The endogenous
  • hCSF1R(2)

    hCSF1R(2)

    • Strain : Repository Live
    • KI/KO Gene : CSF1R
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Csf
    • Description : The endogenous
  • hCsf1/hCsf1r(BALB/c)

    hCsf1/hCsf1r(BALB/c)

    • Strain : Repository Live
    • KI/KO Gene : CSF1
    • Research Application : Humanized Drug
    • Nomenclature : BALB/cAnSmoc-Cs
    • Description : The endogenous
  • hCSF1/hCSF1R(2)

    hCSF1/hCSF1R(2)

    • Strain : Embryo cryopres
    • KI/KO Gene : CSF1
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Csf
    • Description : hCSF1(NM-HU-190
  • hCTLA-4/hTIGIT

    hCTLA-4/hTIGIT

    • Strain : Embryo cryopres
    • KI/KO Gene : CTLA4
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Ctl
    • Description : hCTLA4(NM-HU-00
  • hCTLA-4/hCCR8(BALB/c)

    hCTLA-4/hCCR8(BALB/c)

    • Strain : Repository Live
    • KI/KO Gene : CCR8
    • Research Application : Humanized Drug
    • Nomenclature : BALB/cAnSmoc-Cc
    • Description : hCTLA4(BALB/c)(
  • hCTLA-4/4-1BB

    hCTLA-4/4-1BB

    • Strain : Embryo cryopres
    • KI/KO Gene : CTLA4
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Ctl
    • Description : This CTLA4 and
  • hDDR1

    hDDR1

    • Strain : Sperm cryoprese
    • KI/KO Gene : Ddr1
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Ddr
    • Description : The endogenous
  • hCXCR6

    hCXCR6

    • Strain : Repository Live
    • KI/KO Gene : Cxcr6
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Cxc
    • Description : The endogenous
  • hCXCR5

    hCXCR5

    • Strain : Sperm cryoprese
    • KI/KO Gene : IFNGR2
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Cxc
    • Description : The endogenous
  • hCXCR4

    hCXCR4

    • Strain : Embryo cryopres
    • KI/KO Gene : Cxcr4
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Cxc
    • Description : The endogenous