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Humanized Knockins

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

  • hTLR7

    hTLR7

    • Strain : Embryo cryopres
    • KI/KO Gene : TLR7
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Tlr
    • Description : The endogenous
  • hTLR2

    hTLR2

    • Strain : Embryo cryopres
    • KI/KO Gene : Tlr2
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Tlr
    • Description : The endogenous
  • hTIMD4

    hTIMD4

    • Strain : Sperm cryoprese
    • KI/KO Gene : Gprc5d
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Tim
    • Description : The endogenous
  • hTNFRSF10B

    hTNFRSF10B

    • Strain : Repository Live
    • KI/KO Gene : Tnfrsf10b
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Tnf
    • Description : The endogenous
  • hTNFR2/hPD-1/hPD-L1

    hTNFR2/hPD-1/hPD-L1

    • Strain : Embryo cryopres
    • KI/KO Gene : Pdcd1
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Tnf
    • Description : hTNFRSF1B(NM-HU
  • hTNFR2/hFCGR2B

    hTNFR2/hFCGR2B

    • Strain : Repository Live
    • KI/KO Gene : Fcgr2b
    • Nomenclature : C57BL/6Smoc-Tnf
    • Research Application : Immunotherapy
    • Description : hTNFRSF1B (NM-H
  • hTNFSF14

    hTNFSF14

    • Strain : Sperm cryoprese
    • KI/KO Gene : Tnfsf14
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Tnf
    • Description : The endogenous
  • hVSIG4

    hVSIG4

    • Strain : Repository Live
    • KI/KO Gene : Vsig4
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Vsi
    • Description : The endogenous
  • hVEGFA(2)

    hVEGFA(2)

    • Strain : Repository Live
    • KI/KO Gene : Vegfa
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Veg
    • Description : The endogenous
  • hVEGFA

    hVEGFA

    • Strain : Repository Live
    • KI/KO Gene : Vegfa
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Veg
    • Description : The endogenous
  • hFCRN(3)

    hFCRN(3)

    • Strain : Embryo cryopres
    • KI/KO Gene : Fcgrt
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Fcg
    • Description : The endogenous
  • hFCRN

    hFCRN

    • Strain : Embryo cryopres
    • KI/KO Gene : FCGRT
    • Research Application : Cancer Research
    • Nomenclature : C57BL/6Smoc-Gt(
    • Description : This FcRn human
  • hFCGR2B/hOX40

    hFCGR2B/hOX40

    • Strain : Embryo cryopres
    • KI/KO Gene : Fcgr2b
    • Nomenclature : C57BL/6Smoc-Fcg
    • Research Application : Humanized Drug
    • Description : hFCGR2B(NM-HU-2
  • hFCGR2B/hCD40

    hFCGR2B/hCD40

    • Strain : Repository Live
    • KI/KO Gene : Fcgr2b
    • Nomenclature : C57BL/6Smoc-Fcg
    • Research Application : Humanized Drug
    • Description : hFCGR2B(NM-HU-2
  • hFCGR2B

    hFCGR2B

    • Strain : Repository Live
    • KI/KO Gene : Fcgr2b
    • Nomenclature : C57BL/6Smoc-Fcg
    • Research Application : Immunotherapy
    • Description : The endogenous
  • hFCGR2A

    hFCGR2A

    • Strain : Repository Live
    • KI/KO Gene : Fcgr2b
    • Nomenclature : C57BL/6Smoc-Fcg
    • Research Application : Immunotherapy
    • Description : The endogenous
  • hGEM

    hGEM

    • Strain : Embryo cryopres
    • KI/KO Gene : Gem
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Gem
    • Description : The endogenous
  • hFOXP2

    hFOXP2

    • Strain : Embryo cryopres
    • KI/KO Gene : Foxp2
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Fox
    • Description : The endogenous
  • hFCRN(NOD-scid)

    hFCRN(NOD-scid)

    • Strain : Repository Live
    • KI/KO Gene : Fcgrt
    • Research Application : Immunotherapy
    • Nomenclature : NOD-PrkdcscidFc
    • Description : The endogenous
  • hHGF(NOD-scid)

    hHGF(NOD-scid)

    • Strain : Embryo cryopres
    • KI/KO Gene : Hgf
    • Research Application : Immunotherapy
    • Nomenclature : NOD-PrkdcscidHg
    • Description : The endogenous
  • hHER3(2)

    hHER3(2)

    • Strain : Repository Live
    • KI/KO Gene : Erbb3
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Erb
    • Description : The endogenous
  • hGPR75

    hGPR75

    • Strain : Sperm cryoprese
    • KI/KO Gene : Tfrc
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Gpr
    • Description : The endogenous
  • hICOSL(2)

    hICOSL(2)

    • Strain : Embryo cryopres
    • KI/KO Gene : Icosl
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Ico
    • Description : The endogenous
  • hICOSL

    hICOSL

    • Strain : Embryo cryopres
    • KI/KO Gene : ICOSL
    • Research Application : Immunotherapy
    • Nomenclature : C57BL/6Smoc-Ico
    • Description : The endogenous
  • hIL10RA

    hIL10RA

    • Strain : Sperm cryoprese
    • KI/KO Gene : Il10ra
    • Research Application : Humanized Drug
    • Nomenclature : C57BL/6Smoc-Il1
    • Description : The endogenous