Sacubitril hemicalcium salt

Mfr.No.	T4200
Alternative Names	AHU377 calcium salt
Molecular Formula	C48H56CaN2O10
Signaling Pathways	Metabolism
Description	Sacubitril hemicalcium salt (AHU377 calcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696. Sacubitril hemicalcium salt is a prodrug of LBQ657, which is an inhibitor of the zinc metallopeptidase neprilysin. Neprilysin degrades a variety of vasoactive peptides such as atrial and brain natriuretic peptide, bradykinin, adrenomedullin, and endothelin-1. Inhibition of neprilysin leads to an increased level of these peptides and, thus, antihypertensive effects. Formulations containing AHU377 in combination with the angiotensin II receptor antagonist valsartan are used to treat hypertension and heart failure.
Smiles	(Ca++).CCOC(=O)(CH)(C)C(CH)(Cc1ccc(cc1)-c1ccccc1)NC(=O)CCC((O-))=O.CCOC(=O)(CH)(C)C(CH)(Cc1ccc(cc1)-c1ccccc1)NC(=O)CCC((O-))=O
Cas Number	1369773-39-6
Molecular Weight	861.06
Target	Neprilysin

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SKU	Supplier No.	Size	Your price
BHB20429039	T4200	1 mL	$58	Add to Cart
BHB20429039	T4200	2 mg	$33	Add to Cart
BHB20429039	T4200	5 mg	$48	Add to Cart
BHB20429039	T4200	25 mg	$86	Add to Cart
BHB20429039	T4200	50 mg	$108	Add to Cart
BHB20429039	T4200	100 mg	$157	Add to Cart
BHB20429039	T4200	200 mg	$217	Add to Cart