ELISA Kit for Rat Hemojuvelin

Mfr.No.	E1077r
Alternative Names	Hemochromatosis type 2 protein homolog ; RGM domain family member C ; Rgmc
Categories	Elisa
Function	Member of the repulsive guidance molecule (RGM) family. Involved in iron metabolism (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor (By similarity). Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism (By similarity). May cooperate with hepcidin to restrict iron absorption in the gut (By similarity). Could represent the cellular receptor for hepcidin.
Specificity	Natural and recombinant Rat Hemojuvelin
Subcellular Location	Cell membrane Lipid-anchor GPI-anchor
Detection Range	78-5000pg/mL
Entryname	RGMC_RAT
Method Type	Sandwich
Platform	PF06534
Protein Name	Hemojuvelin
Sensitivity	40.7pg/mL
Sequence	50: MGDRGRSPSL ; RSPHGSPPTL ; STLTLLLLLC ; GQAHSQCKIL ; RCNAEYVSFT ; 100: LSLRGGGSPD ; TPRGGGRGGP ; ASGGLCRALR ; SYALCTRRTA ; RTCRGDLAFH ; 150: SAVHGIEDLM ; IQHNCSRQGP ; TASPPARGPA ; LPGAGPAPLT ; PDPCDYEARF ; 200: SRLHGRTPGF ; LHCASFGDPH ; VRSFHNHFHT ; CRVQGAWPLL ; DNDFLFVQAT ; 250: SSPVASGANA ; TTIRKITIIF ; KNMQECIDQK ; VYQAEVDNLP ; AAFEDGSVNG ; 300: GDRPGGSSLS ; IQTANLGSHV ; EIRAAYIGTT ; IIVRQTAGQL ; SFSIRVAEDV ; 350: ARAFSAEQDL ; QLCVGGCPPS ; QRLSRSERNR ; RGAIAIDTAR ; RLCKEGLPVE ; 400: DAYFQSCVFD ; VSVSGDPNFT ; VAAQSALDDA ; RVFLTDLENL ; HLFPVDAGPP ; 422: LSPATCLVRL ; LSVLFVLWFC ; IQ
Sequence Length	422
String	Q8N7M5
Sub Unit	Interacts with BMP2, BMP4, and BMPR1B.

Reference	1. Isogai T., Yamamoto J. Submitted (2002-07) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Trachea. 2. "Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis." Papanikolaou G., Samuels M.E., Ludwig E.H., MacDonald M.L.E., Franchini P.L., Dube M.-P., Andres L., MacFarlane J., Sakellaropoulos N., Politou M., Nemeth E., Thompson J., Risler J.K., Zaborowska C., Babakaiff R., Radomski C.C., Pape T.D., Davidas O., Christakis J., Brissot P., Lockitch G., Ganz T., Hayden M.R., Goldberg Y.P.more... Nat. Genet.36:77-82(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SHOWS THAT SEQUENCE DESCRIBED BY ISOGAI ET AL ORIGINATE FROM RAT

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BHE13809114	E1077r	96T	$796		Add to Cart