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ELISA Kit for Rat Gamma-aminobutyric acid type B receptor subunit 1

SKU : BHE13805047

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2151r
Categories	Elisa
Function	Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
Specificity	Natural and recombinant Rat Gamma-aminobutyric acid type B receptor subunit 1
Subcellular Location	Cell membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. Colocalizes with ATF4 in hippocampal neuron dendritic membranes.
Detection Range	0.156-10ng/mL
Entryname	GABR1_RAT
Method Type	Sandwich
Platform	PF00003
Protein Name	Gamma-aminobutyric acid type B receptor subunit 1
Sensitivity	0.093ng/mL
Sequence	50: MLLLLLVPLF ; LRPLGAGGAQ ; TPNATSEGCQ ; IIHPPWEGGI ; RYRGLTRDQV ; 100: KAINFLPVDY ; EIEYVCRGER ; EVVGPKVRKC ; LANGSWTDMD ; TPSRCVRICS ; 150: KSYLTLENGK ; VFLTGGDLPA ; LDGARVEFRC ; DPDFHLVGSS ; RSVCSQGQWS ; 200: TPKPHCQVNR ; TPHSERRAVY ; IGALFPMSGG ; WPGGQACQPA ; VEMALEDVNS ; 250: RRDILPDYEL ; KLIHHDSKCD ; PGQATKYLYE ; LLYNDPIKII ; LMPGCSSVST ; 300: LVAEAARMWN ; LIVLSYGSSS ; PALSNRQRFP ; TFFRTHPSAT ; LHNPTRVKLF ; 350: EKWGWKKIAT ; IQQTTEVFTS ; TLDDLEERVK ; EAGIEITFRQ ; SFFSDPAVPV ; 400: KNLKRQDARI ; IVGLFYETEA ; RKVFCEVYKE ; RLFGKKYVWF ; LIGWYADNWF ; 450: KTYDPSINCT ; VEEMTEAVEG ; HITTEIVMLN ; PANTRSISNM ; TSQEFVEKLT ; 500: KRLKRHPEET ; GGFQEAPLAY ; DAIWALALAL ; NKTSGGGGRS ; GVRLEDFNYN ; 550: NQTITDQIYR ; AMNSSSFEGV ; SGHVVFDASG ; SRMAWTLIEQ ; LQGGSYKKIG ; 600: YYDSTKDDLS ; WSKTDKWIGG ; SPPADQTLVI ; KTFRFLSQKL ; FISVSVLSSL ; 650: GIVLAVVCLS ; FNIYNSHVRY ; IQNSQPNLNN ; LTAVGCSLAL ; AAVFPLGLDG ; 700: YHIGRSQFPF ; VCQARLWLLG ; LGFSLGYGSM ; FTKIWWVHTV ; FTKKEEKKEW ; 750: RKTLEPWKLY ; ATVGLLVGMD ; VLTLAIWQIV ; DPLHRTIETF ; AKEEPKEDID ; 800: VSILPQLEHC ; SSKKMNTWLG ; ELWSFAVSSD ; VQRRATVGGD ; SPICVWPAPE ; 850: SIFYGYKGLL ; LLLGIFLAYE ; TKSVSTEKIN ; DHRAVGMAIY ; NVAVLCLITA ; 900: PVTMILSSQQ ; DAAFAFASLA ; IVFSSYITLV ; VLFVPKMRRL ; ITRGEWQSET ; 950: QDTMKTGSST ; NNNEEEKSRL ; LEKENRELEK ; IIAEKEERVS ; ELRHQLQSRQ ; 991: QLRSRRHPPT ; PPDPSGGLPR ; GPSEPPDRLS ; CDGSRVHLLY ; K
Sequence Length	991
String	Q9Z0U4
Sub Unit	Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1.

Uniprot	Q9Z0U4
Gene Name	Gabbr1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:81657
Unigene	Rn.30059

Reference	1. "Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors." Kaupmann K., Huggel K., Heid J., Flor P.J., Bischoff S., Mickel S.J., McMaster G., Angst C., Bittiger H., Froestl W., Bettler B. Nature386:239-246(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 1B);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY strain: RICO. tissue: Brain cortex. tissue: Cerebellum. 2. "Cloning and tissue distribution of novel splice variants of the rat GABAB receptor." Isomoto S., Kaibara M., Sakurai-Yamashita Y., Nagayama Y., Uezono Y., Yano K., Taniyama K. Biochem. Biophys. Res. Commun.253:10-15(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1C AND 1D);TISSUE SPECIFICITY tissue: Cerebellum. 3. "Alternative splicing generates a novel isoform of the rat metabotropic GABA(B)R1 receptor." Pfaff T., Malitschek B., Kaupmann K., Prezeau L., Pin J.-P., Bettler B., Karschin A. Eur. J. Neurosci.11:2874-2882(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORM 1E) strain: Wistar. tissue: Hippocampus. 4. "Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity." Ng G.Y.K., Clark J., Coulombe N., Ethier N., Hebert T.E., Sullivan R., Kargman S., Chateauneuf A., Tsukamoto N., McDonald T., Whiting P., Mezey E., Johnson M.P., Liu Q., Kolakowski L.F. Jr., Evans J.F., Bonner T.I., O'Neill G.P. J. Biol. Chem.274:7607-7610(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A);INTERACTION WITH GABBR2 tissue: Brain. 5. "Synthesis of the nanomolar photoaffinity GABA(B) receptor ligand CGP 71872 reveals diversity in the tissue distribution of GABA(B) receptor forms." Belley M., Sullivan R., Reeves A., Evans J.F., O'Neill G.P., Ng G.Y.K. Bioorg. Med. Chem.7:2697-2704(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY 6. "Role of heteromer formation in GABAB receptor function." Kuner R., Koehr G., Gruenewald S., Eisenhardt G., Bach A., Kornau H.-C. Science283:74-77(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GABBR2 7. "The metabotropic GABAB receptor directly interacts with the activating transcription factor 4." Nehring R.B., Horikawa H.P.M., El Far O., Kneussel M., Brandstatter J.H., Stamm S., Wischmeyer E., Betz H., Karschin A. J. Biol. Chem.275:35185-35191(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATF4;SUBCELLULAR LOCATION 8. "Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit." Galvez T., Urwyler S., Prezeau L., Mosbacher J., Joly C., Malitschek B., Heid J., Brabet I., Froestl W., Bettler B., Kaupmann K., Pin J.-P. Mol. Pharmacol.57:419-426(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-247; SER-268 AND SER-269 9. "Marlin-1, a novel RNA-binding protein associates with GABA receptors." Couve A., Restituito S., Brandon J.M., Charles K.J., Bawagan H., Freeman K.B., Pangalos M.N., Calver A.R., Moss S.J. J. Biol. Chem.279:13934-13943(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JAKMIP1 10. "Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded." Blein S., Ginham R., Uhrin D., Smith B.O., Soares D.C., Veltel S., McIlhinney R.A., White J.H., Barlow P.N. J. Biol. Chem.279:48292-48306(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 96-159;DISULFIDE BONDS

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