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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Endoplasmic reticulum aminopeptidase 1

SKU : BHE13804305

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E12631r
Alternative Names	ARTS-1 ; Adipocyte-derived leucine aminopeptidase ; A-LAP ; Aminopeptidase PILS ; Puromycin-insensitive leucyl-specific aminopeptidase ; PILS-AP ; Appils ; Arts1
Categories	Elisa
Function	Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
Specificity	Natural and recombinant Rat Endoplasmic reticulum aminopeptidase 1
Subcellular Location	Endoplasmic reticulum membrane Single-pass type II membrane protein
Entryname	ERAP1_RAT
Platform	PF11838
Protein Name	Endoplasmic reticulum aminopeptidase 1
Sequence	50: MPSLLSLVLT ; FLAVSSPSCC ; QNSDTASPKA ; SNGASFPWNN ; MRLPEYITPI ; 100: HYDLMIHANL ; STLTFWGKTE ; VEITVSQPTS ; TIIMHSHQLQ ; ISKATLRRGA ; 150: EEMLPEEPLK ; LMEYSAHEQV ; ALLTAQPLLA ; GSVYTVIITY ; AANLSENFHG ; 200: FYKSTYRTQE ; GERRILAATQ ; FEPTAARMAF ; PCFDEPALKA ; SFSIKIKRDP ; 250: RHLAISNMPL ; VKSVTVAEGL ; IEDHFDITVK ; MSTYLVAFII ; SDFKSVSKMT ; 300: KSGVKVSVYA ; VPDKINQADY ; ALDAAVTLLE ; FYEDYFSIPY ; PLPKQDLAAI ; 350: PDFQSGAMEN ; WGLTTYRESA ; LLYDKEKSSA ; SSKLGITMTV ; SHELAHQWFG ; 400: NLVTMEWWND ; LWLNEGFAKF ; MEFVSVTVTH ; PELKVEEYFF ; GKCFNAMEVD ; 450: ALNSSHPVST ; PVENPAQIRE ; MFDEVSYEKG ; ACILNMLRDY ; LSADTFKRGI ; 500: VQYLQKYSYK ; NTKNEDLWNS ; MMHICPTDGT ; QTMDGFCSRN ; QHSSSTSHWR ; 550: QEVIDIKSMM ; NTWTLQKGFP ; LITITVRGRN ; VHLKQEHYMK ; GSECFPETGS ; 600: LWHVPLTFIT ; SKSDSVQRFL ; LKTKTDVIIL ; PEAVEWIKFN ; VGMNGYYIVH ; 650: YGDDGWASLN ; GLLKEAHTTI ; SSNDRASLIN ; NAFQLVSIGK ; LSIEKALDLI ; 700: LYLKNETEIM ; PIFQGLNELI ; PMYKLMEKRD ; MVEVETQFKD ; FLLRLLKDLI ; 750: NKQTWTDEGS ; VSERMLRSQL ; LLLACVHRYQ ; LCVQRAERYF ; REWKASNGNM ; 800: SLPIDVTLAV ; FAVGAQNTEG ; WDFLYSKYQS ; SLSSTEKSQI ; EFSLCISQDP ; 850: EKLQWLLDQS ; FKGEIIKTQE ; FPHILTLIGR ; NPVGYPLAWK ; FLKENWNKIV ; 900: QKFELGSSSI ; AHMVMGTTNQ ; FSTRARLEEV ; KGFFSSLKKN ; GSQLRCVQQT ; 930: IETIEENIRW ; MDKNFDKIRL ; WLQKERQELL ;
Sequence Length	930
String	Q9JJ22
Sub Unit	Monomer. May also exist as a heterodimer; with ERAP2. Interacts with RBMX.

Uniprot	Q9JJ22
Gene Name	Erap1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:80897
Unigene	Rn.22516

Reference	1. "Molecular characterization of a puromycin-insensitive leucyl-specific aminopeptidase, PILS-AP." Schomburg L., Kollmus H., Friedrichsen S., Bauer K. Eur. J. Biochem.267:3198-3207(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY strain: Sprague-Dawley. tissue: Pineal gland.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13804305	E12631r	96T	$796		Add to Cart

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