ELISA Kit for Rat Calcineurin-binding protein cabin-1

Mfr.No.

E6266r

Alternative Names

Calcineurin inhibitor ; CAIN

Categories

Elisa

Function

May be required for replication-independent chromatin assembly (By similarity). May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin.

Specificity

Natural and recombinant Rat Calcineurin-binding protein cabin-1

Subcellular Location

Nucleus Cytoplasm

Entryname

CABIN_RAT

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-102%	90-104%	95-100%	91-103%
EDTA plasma(n=5)	89-107%	93-105%	91-106%	90-108%
heparin plasma(n=5)	93-104%	94-101%	95-101%	91-105%

Platform

PF09047

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤7.3%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤12.3%

Protein Name

Calcineurin-binding protein cabin-1

Recovery

Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	97	91-103
Plasma	98	93-106

Sequence

50:

MIRIAALNAS ; STIEDDHEGS ; FKSHKIQTKE ; AQEAEAFALY ; HKALDLQKHD ;

100:

RFEESAKAYH ; ELLEARLLRE ; AVSSGDEKEG ; LKHPGLILKY ; STYKNLAQLA ;

150:

AQREDLETAM ; EFYLEAVMLD ; STDVNLWYKI ; GHVALRLIRL ; PLARHAFEEG ;

200:

LRCNPDHWPC ; LDNLITVLYT ; LSDYTTCLYF ; ICKALEKDCR ; YSKGLVLKEK ;

250:

IFEEQPCLRK ; DSLRMFLKCD ; MSVHEVSVNA ; AETQAIVDEA ; LGLRKKRQAL ;

300:

IVREKEPDLK ; LVQPIPFFTW ; KCLGESLLAM ; YNHLTTCEPP ; RPSLGKRIDL ;

350:

SDYQDPSQLL ; APSIVVTPVS ; VVQPSPVCTN ; PTVAVAEPVL ; SYTSVTTTSF ;

400:

PLHSPGLLDT ; GTPMGDVSGG ; DKSKKGVKRK ; KTLEESGETA ; KRRSARVRNT ;

450:

KCKKEEKVDF ; QGLLVKFLPS ; RLRKLDPEEE ; DDPFNNYEVQ ; SEAKLESFSN ;

500:

VGPHRLSFDS ; ATFMESEKQD ; VHAFLMENLT ; NGGVLELMMR ; YLKSMGHKFL ;

550:

LKWPPGLAEV ; VLSVYHSWRR ; HSTSLPNPLL ; RDCSNKHIKD ; MMLMSLSCME ;

600:

LQLDQWLLTK ; GRSSTVSPRN ; CPAGVVTGRF ; GPDFPGTHCL ; GDLLQLSFAS ;

650:

SQRDLFEDGW ; LEFVVRVYWL ; KARFLALQGD ; MEQALENYDI ; CTEILQSSTA ;

700:

LQAQAGAEQR ; DIVIRLPNLH ; NDSIVSLEEI ; DKNLKSLERC ; QSLEEIQRLF ;

750:

EAGDYKAVVQ ; LLRPTLCTSG ; FDRAKHLEFM ; TSIPERPAQL ; LLLQDSLLRL ;

800:

EEHRQCFECS ; DVALNEAVQQ ; MLNSSDSAAK ; EEWAATVTQL ; LLGMEQALSS ;

850:

DSRGSILKES ; SSPTGLVRLT ; NNLIQVIDCS ; MAVQEEPKEP ; YVSSVLPWII ;

900:

LHRIIWQEED ; TFRSLCHQQQ ; LQNPTEEGIS ; EMPMLPSSLM ; LLNTAHEYLG ;

950:

RRSWCCNSDG ; ALLRFYVHVL ; QKELAASASE ; DTHPYKEELE ; TALEQCFYCL ;

1000:

YSFPSKKSKA ; RYLEEHSAQQ ; VDLTWEDALF ; MFEYFKPKTL ; PEFDSYKTST ;

1050:

VSADLANLLK ; RIATIVPRTE ; KPALSMDKVS ; AYIEGTSAEV ; PCLPDGADPA ;

1100:

PPVLNELYYL ; LADYHFKNKE ; QSKAIKFYMH ; DICICPNRFD ; SWAGMALARA ;

1150:

SRIQDKLNSN ; ELKSDGPIWR ; HATPVLNCFR ; RALEIDSSNL ; SLWIEYGTMS ;

1200:

YALHSFASRQ ; LKQWRAELPP ; EVVQQMEDRR ; DSMLETARHC ; FTSAAHCEGD ;

1250:

GDEEEWLIHY ; MLGKVAEKQQ ; QPPTVYLLHY ; RQAGHYLHEE ; AARYPKKIHY ;

1300:

HNPPELAMEA ; LEVYFRLHAS ; ILKLLGKPDS ; GVSAEVLVSF ; MKEAAEGPFA ;

1350:

RGEEKNTPKA ; SEKEKACLVD ; EDSHSSAGTL ; PGPGASLPSS ; SGPGLTSPPY ;

1400:

TATPIDHDYV ; KCKKPRQQAT ; PDDRSQDSTA ; VALSDSSSTQ ; DFFNEPTSLL ;

1450:

DGSRKLLPEK ; RISGLSAQAG ; PSGKDLPGPT ; EERGKTEESL ; ESTEAFRVVE ;

1500:

PSVQKPVADS ; SASAYIPSKP ; AVSTPPPWDG ; KKRSDPLGEP ; VAFPQGLPAG ;

1550:

AEEQRQFLTE ; QCIASFCLCL ; SRFPQHYKSL ; YRLAFLYTYS ; KTHRNLQWAR ;

1600:

DVLLGSSIPW ; QQLQHMPAQG ; LFCERNKTNF ; FNGIWRIPVD ; EIDRPGSFAW ;

1650:

HMNRSIVLLL ; KVLAQLRDHS ; TLLKVSSMLQ ; RTPDQGKKYL ; RDADRQVLAQ ;

1700:

RAFILTVKVL ; EDTLSELAEG ; LEHPGSKACG ; LSGARMTTDV ; SHKASPEDGQ ;

1750:

ESLPHPKKLP ; LADGSGPGPE ; PGGKVGPLHQ ; LPVATDTRDN ; TEQGGEPKDK ;

1800:

ERPPVGPTEP ; MDTGETAARH ; PDLEPTPRLL ; PGRPPRDRGP ; ESRSAELSLE ;

1850:

ELSISTRQQP ; APLVPSPVTP ; TTAAPTTMGA ; RAAGHPEEAP ; PRPNRKRKLL ;

1900:

QDTESGKTLL ; LDAYRVWQQG ; QKAMAYDLSR ; IEKIMSETYM ; LIKQVDEETA ;

1950:

LEQAVKFCQV ; HLGAAAQRQA ; SGDAPTTPKH ; PKDSRENFFP ; ATVAPSAPDT ;

2000:

TAPDALQRPS ; DSHLKPGLAA ; AITCPPSASA ; STPDPGIPQP ; HRPEAVPSRA ;

2050:

PLSPDGEEVS ; GVTEGPSFLS ; QEPRHSHQMK ; MAATGPLAEQ ; HCWPVEAACQ ;

2100:

TGAEPTFSQA ; TSTKVPSSGS ; TQTPESHQGK ; TESSRAKSRL ; LPNMPKLVIP ;

2150:

SATTKFPPEI ; TVTPPTPTLL ; SPKGSISEET ; KQKLKSAILS ; AQSAANVRKE ;

2182:

SLCQPALEVL ; ETSSQESSLE ; SETDEDDDFM ; DV

Sequence Length

2182

String

O88480

Sub Unit

Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1 (By similarity). Interacts with MEF2B (By similarity). Interacts with calcineurin.

Uniprot	O88480
Gene Name	Cabin1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:94165
Unigene	Rn.4

Reference	1. "Cain, a novel physiologic protein inhibitor of calcineurin." Lai M.M., Burnett P.E., Wolosker H., Blackshaw S., Snyder S.H. J. Biol. Chem.273:18325-18331(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH CALCINEURIN;SUBCELLULAR LOCATION;TISSUE SPECIFICITY tissue: Hippocampus.

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BHE13801625	E6266r	96T	$796		Add to Cart

ELISA Kit for Rat Calcineurin-binding protein cabin-1

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