ELISA Kit for Pig Thyroxine 5-deiodinase

Mfr.No.	E12263p
Alternative Names	5DIII ; DIOIII ; Type 3 DI ; Type III iodothyronine deiodinase
Categories	Elisa
Function	Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
Specificity	Natural and recombinant Pig Thyroxine 5-deiodinase
Subcellular Location	Cell membrane Single-pass type II membrane protein Endosome membrane Single-pass type II membrane protein
Entryname	IOD3_PIG
Method Type	Sandwich
Platform	PF00837
Protein Name	Thyroxine 5-deiodinase
Sequence	50: MLHSLLLHSL ; RLCAQTASCL ; VLFPRFLGTA ; CMLWLLDFLC ; IRKHLLGRRR ; 100: RGEPETEVEL ; NSDGDEVPPD ; DPPICVSDDN ; RLCTLASLRA ; VWHGQKLDFF ; 150: KQAHEGGPAP ; NSEVVLPDGF ; QNQHILDYAR ; GNRPLVLNFG ; SCTUPPFMAR ; 200: MSAFQRLVTK ; YQRDVDFLII ; YIEEAHPSDG ; WVTTDSPYSI ; PQHRSLEDRV ; 250: SAARVLQQGA ; PECSLVLDTM ; ANSSSSAYGA ; YFERLYVIQS ; GTIMYQGGRG ; 278: PDGYQVSELR ; TWLERYDQQL ; HGPQPRRV
Sequence Length	278
Sub Unit	Homodimer. May undergo minor heretodimerization with DIO1 and DIO2.

Reference	1. Porcine genome sequencing project Submitted (2009-11) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 2. "Characteristics and thyroid state-dependent regulation of iodothyronine deiodinases in pigs." Wassen F.W.J.S., Klootwijk W., Kaptein E., Duncker D.J., Visser T.J., Kuiper G.G.J.M. Endocrinology145:4251-4263(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-305;FUNCTION;TISSUE SPECIFICITY strain: Landrace X Yorkshire. tissue: Brain.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805644	E12263p	96T	$900		Add to Cart