Participates in the innate immune response to Gram-positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Cooperates with TLR2 for the cellular activation.
Specificity
Natural and recombinant Mouse Toll-like receptor 6
Subcellular Location
Cell membrane Single-pass type I membrane protein Cytoplasmic vesicle phagosome membrane Single-pass type I membrane protein
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];MUTAGENESIS OF PRO-680
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 1-483 IN COMPLEX WITH TLR2 AND LIPOPEPTIDE;DISULFIDE BONDS;GLYCOSYLATION AT ASN-144; ASN-195; ASN-214; ASN-253; ASN-359; ASN-401 AND ASN-434;FUNCTION;LRR REPEATS;SUBUNIT
Reviews of ELISA Kit for Mouse Toll-like receptor 6