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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Protein kinase C alpha type

SKU : BHE13806284

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1380m
Alternative Names	Pkca
Categories	Elisa
Function	PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
Specificity	Natural and recombinant Mouse Protein kinase C alpha type
Subcellular Location	Cytoplasm Cell membrane Peripheral membrane protein Nucleus
Detection Range	31.2-2000pg/ml
Entryname	KPCA_MOUSE
Method Type	Sandwich
Platform	PF00130
Protein Name	Protein kinase C alpha type
Sensitivity	15.6pg/mL
Sequence	50: MADVYPANDS ; TASQDVANRF ; ARKGALRQKN ; VHEVKDHKFI ; ARFFKQPTFC ; 100: SHCTDFIWGF ; GKQGFQCQVC ; CFVVHKRCHE ; FVTFSCPGAD ; KGPDTDDPRS ; 150: KHKFKIHTYG ; SPTFCDHCGS ; LLYGLIHQGM ; KCDTCDMNVH ; KQCVINDPSL ; 200: CGMDHTEKRG ; RIYLKAEVTD ; EKLHVTVRDA ; KNLIPMDPNG ; LSDPYVKLKL ; 250: IPDPKNESKQ ; KTKTIRSNLN ; PQWNESFTFK ; LKPSDKDRRL ; SVEIWDWDRT ; 300: TRNDFMGSLS ; FGVSELMKMP ; ASGWYKAHNQ ; EEGEYYNVPI ; PEGDEEGNME ; 350: LRQKFEKAKL ; GPVGNKVISP ; SEDRKQPSNN ; LDRVKLTDFN ; FLMVLGKGSF ; 400: GKVMLADRKG ; TEELYAIKIL ; KKDVVIQDDD ; VECTMVEKRV ; LALLDKPPFL ; 450: TQLHSCFQTV ; DRLYFVMEYV ; NGGDLMYHIQ ; QVGKFKEPQA ; VFYAAEISIG ; 500: LFFLHKRGII ; YRDLKLNNVM ; LNSEGHIKIA ; DFGMCKEHMM ; DGVTTRTFCG ; 550: TPDYIAPEII ; AYQPYGKSVD ; WWAYGVLLYE ; MLAGQPPFDG ; EDEDELFQSI ; 600: MEHNVSYPKS ; LSKEAVSICK ; GLMTKQPAKR ; LGCGPEGERD ; VREHAFFRRI ; 650: DWEKLENREI ; QPPFKPKVCG ; KGAENFDKFF ; TRGQPVLTPP ; DQLVIANIDQ ; 672: SDFEGFSYVN ; PQFVHPILQS ; AV
Sequence Length	672
String	P20444
Sub Unit	Interacts with ADAP1/CENTA1, CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine (By similarity). Interacts with PICK1 (via PDZ domain) (By similarity). Interacts with TRIM41 (By similarity). Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and GNB2L1/RACK1.

Uniprot	P20444
Gene Name	Prkca
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:18750
Unigene	Mm.222178

Reference	1. "Molecular cloning of mouse protein kinase C (PKC) cDNA from Swiss 3T3 fibroblasts." Rose-John S., Dietrich A., Marks F. Gene74:465-471(1988) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "A mutant protein kinase C that can transform fibroblasts." Megidish T., Mazurek N. Nature342:807-811(1989) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS VAL-106; GLY-111; GLN-240 AND LEU-339 strain: BALB/c. tissue: Brain. 3. "Protein kinase C alpha activates RAF-1 by direct phosphorylation." Kolch W., Heidecker G., Kochs G., Hummel R., Vahidi H., Mischak H., Finkenzeller G., Marme D., Rapp U.R. Nature364:249-252(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF RAF1 4. "PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system." Staudinger J., Zhou J., Burgess R., Elledge S.J., Olson E.N. J. Cell Biol.128:263-271(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRKCABP 5. "An activated protein kinase C alpha gives a differentiation signal for hematopoietic progenitor cells and mimicks macrophage colony-stimulating factor-stimulated signaling events." Pierce A., Heyworth C.M., Nicholls S.E., Spooncer E., Dexter T.M., Lord J.M., Owen-Lynch P.J., Wark G., Whetton A.D. J. Cell Biol.140:1511-1518(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL PROLIFERATION 6. "Imaging protein kinase Calpha activation in cells." Ng T., Squire A., Hansra G., Bornancin F., Prevostel C., Hanby A., Harris W., Barnes D., Schmidt S., Mellor H., Bastiaens P.I., Parker P.J. Science283:2085-2089(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION 7. "A Ras activation pathway dependent on Syk phosphorylation of protein kinase C." Kawakami Y., Kitaura J., Yao L., McHenry R.W., Kawakami Y., Newton A.C., Kang S., Kato R.M., Leitges M., Rawlings D.J., Kawakami T. Proc. Natl. Acad. Sci. U.S.A.100:9470-9475(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-658 8. "PKCalpha regulates platelet granule secretion and thrombus formation in mice." Konopatskaya O., Gilio K., Harper M.T., Zhao Y., Cosemans J.M., Karim Z.A., Whiteheart S.W., Molkentin J.D., Verkade P., Watson S.P., Heemskerk J.W., Poole A.W. J. Clin. Invest.119:399-407(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PLATELET GRANULE SECRETION 9. "Identification of RACK1 and protein kinase Calpha as integral components of the mammalian circadian clock." Robles M.S., Boyault C., Knutti D., Padmanabhan K., Weitz C.J. Science327:463-466(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BMAL1 AND GNB2L1;SUBCELLULAR LOCATION

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