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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse POU domain, class 5, transcription factor 1

SKU : BHE13808927

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1533m
Alternative Names	NF-A3 ; Octamer-binding protein 3 ; Oct-3 ; Octamer-binding protein 4 ; Oct-4 ; Octamer-binding transcription factor 3 ; OTF-3 ; Oct-3 ; Oct-4 ; Otf-3 ; Otf3
Categories	Elisa
Function	Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
Specificity	Natural and recombinant Mouse POU domain, class 5, transcription factor 1
Subcellular Location	Nucleus Expressed in a diffuse and slightly punctuate pattern.
Detection Range	0.156-10ng/mL
Entryname	PO5F1_MOUSE
Method Type	Sandwich
Platform	PF00046
Protein Name	POU domain, class 5, transcription factor 1
Sensitivity	0.082ng/mL
Sequence	50: MAGHLASDFA ; FSPPPGGGDG ; SAGLEPGWVD ; PRTWLSFQGP ; PGGPGIGPGS ; 100: EVLGISPCPP ; AYEFCGGMAY ; CGPQVGLGLV ; PQVGVETLQP ; EGQAGARVES ; 150: NSEGTSSEPC ; ADRPNAVKLE ; KVEPTPEESQ ; DMKALQKELE ; QFAKLLKQKR ; 200: ITLGYTQADV ; GLTLGVLFGK ; VFSQTTICRF ; EALQLSLKNM ; CKLRPLLEKW ; 250: VEEADNNENL ; QEICKSETLV ; QARKRKRTSI ; ENRVRWSLET ; MFLKCPKPSL ; 300: QQITHIANQL ; GLEKDVVRVW ; FCNRRQKGKR ; SSIEYSQREE ; YEATGTPFPG ; 350: GAVSFPLPPG ; PHFGTPGYGS ; PHFTTLYSVP ; FPEGEAFPSV ; PVTALGSPMH ; 352: SN
Sequence Length	352
String	P20263
Sub Unit	Interacts with PKM2. Interacts with WWP2 (By similarity). Interacts with UBE2I and ZSCAN10.

Uniprot	P20263
Gene Name	Pou5f1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:18999
Unigene	Mm.17031

Reference	1. "A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo." Rosner M.H., Vigano M.A., Ozato K., Timmons P.M., Poirier F., Rigby P.W.J., Staudt L. Nature345:686-692(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;DEVELOPMENTAL STAGE tissue: Embryonic carcinoma. 2. "New type of POU domain in germ line-specific protein Oct-4." Schoeler H.R., Ruppert S., Suzuki N., Chowdhury K., Gruss P. Nature344:435-439(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;INDUCTION tissue: Embryonic carcinoma. 3. "A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells." Okamoto K., Okazawa H., Okuda A., Sakai M., Muramatsu M., Hamada H. Cell60:461-472(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 4. "The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer." Okazawa H., Okamoto K., Ishino F., Ishino-Kaneko T., Takeda S., Toyoda Y., Muramatsu M., Hamada H. EMBO J.10:2997-3005(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];SEQUENCE REVISION;INDUCTION 5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: C57BL/6J. tissue: Embryo. 6. "Inhibition of DNA binding of Sox2 by the SUMO conjugation." Tsuruzoe S., Ishihara K., Uchimura Y., Watanabe S., Sekita Y., Aoto T., Saitoh H., Yuasa Y., Niwa H., Kawasuji M., Baba H., Nakao M. Biochem. Biophys. Res. Commun.351:920-926(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-118;MUTAGENESIS OF LYS-118 7. "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors." Takahashi K., Yamanaka S. Cell126:663-676(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOTECHNOLOGY 8. "Post-translational modification of POU domain transcription factor Oct-4 by SUMO-1." Zhang Z., Liao B., Xu M., Jin Y. FASEB J.21:3042-3051(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-118;MUTAGENESIS OF LYS-118; GLU-120; LYS-215 AND LYS-244;FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH UBE2I 9. "Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation." Wei F., Schoeler H.R., Atchison M.L. J. Biol. Chem.282:21551-21560(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-118;MUTAGENESIS OF LYS-118;FUNCTION;SUBCELLULAR LOCATION 10. "Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells." Yu H.B., Kunarso G., Hong F.H., Stanton L.W. J. Biol. Chem.284:31327-31335(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZSCAN10 11. "Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner." Liao B., Jin Y. Cell Res.20:332-344(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION 12. "Secondary structure of the oct-3 POU homeodomain as determined by 1H-15N NMR spectroscopy." Morita E.H., Shirakawa M., Hayashi F., Imagawa M., Kyogoku Y. FEBS Lett.321:107-110(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF POU DOMAIN

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