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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Mothers against decapentaplegic homolog 4

SKU : BHE13809811

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1925m
Alternative Names	Deletion target in pancreatic carcinoma 4 homolog ; SMAD family member 4 ; SMAD 4 ; Dpc4 ; Madh4
Categories	Elisa
Function	Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor.
Specificity	Natural and recombinant Mouse Mothers against decapentaplegic homolog 4
Subcellular Location	Cytoplasm Nucleus In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with R-SMAD.
Detection Range	0.312-20ng/mL
Entryname	SMAD4_MOUSE
Method Type	Sandwich
Platform	PF03165
Protein Name	Mothers against decapentaplegic homolog 4
Sensitivity	0.168ng/mL
Sequence	50: MDNMSITNTP ; TSNDACLSIV ; HSLMCHRQGG ; ESETFAKRAI ; ESLVKKLKEK ; 100: KDELDSLITA ; ITTNGAHPSK ; CVTIQRTLDG ; RLQVAGRKGF ; PHVIYARLWR ; 150: WPDLHKNELK ; HVKYCQYAFD ; LKCDSVCVNP ; YHYERVVSPG ; IDLSGLTLQS ; 200: NAPSMLVKDE ; YVHDFEGQPS ; LPTEGHSIQT ; IQHPPSNRAS ; TETYSAPALL ; 250: APAESNATST ; TNFPNIPVAS ; TSQPASILAG ; SHSEGLLQIA ; SGPQPGQQQN ; 300: GFTAQPATYH ; HNSTTTWTGS ; RTAPYTPNLP ; HHQNGHLQHH ; PPMPPHPGHY ; 350: WPVHNELAFQ ; PPISNHPAPE ; YWCSIAYFEM ; DVQVGETFKV ; PSSCPVVTVD ; 400: GYVDPSGGDR ; FCLGQLSNVH ; RTEAIERARL ; HIGKGVQLEC ; KGEGDVWVRC ; 450: LSDHAVFVQS ; YYLDREAGRA ; PGDAVHKIYP ; SAYIKVFDLR ; QCHRQMQQQA ; 500: ATAQAAAAAQ ; AAAVAGNIPG ; PGSVGGIAPA ; ISLSAAAGIG ; VDDLRRLCIL ; 550: RMSFVKGWGP ; DYPRQSIKET ; PCWIEIHLHR ; ALQLLDEVLH ; TMPIADPQPL ; 551: D
Sequence Length	551
String	P97471
Sub Unit	Monomer (By similarity). Heterotrimer; with a C-terminally phosphorylated R-SMAD molecule and to form the transcriptionally active SMAD2/3-SMAD4 complex (By similarity). Found in a ternary complex composed of SMAD4, STK11/LKB1 and STK11IP. Interacts with ATF2, COPS5, DACH1, MSG1, SKI, STK11/LKB1, STK11IP and TRIM33. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with USP9X. Interacts with RBPMS. Interacts with WWTR1 (via coiled-coil domain). Interacts with CITED1 and CITED2.

Uniprot	P97471
Gene Name	Smad4
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:17128
Unigene	Mm.100399

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809811	E1925m	96T	$776		Add to Cart

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