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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Erythropoietin receptor

SKU : BHE13804233

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0027m
Categories	Elisa
Function	Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
Specificity	Natural and recombinant Mouse Erythropoietin receptor
Subcellular Location	Isoform EPOR-S Secreted
Detection Range	0.156-10ng/mL
Entryname	EPOR_MOUSE
Method Type	Sandwich
Platform	PF09067
Protein Name	Erythropoietin receptor
Sensitivity	0.088ng/mL
Sequence	50: MDKLRVPLWP ; RVGPLCLLLA ; GAAWAPSPSL ; PDPKFESKAA ; LLASRGSEEL ; 100: LCFTQRLEDL ; VCFWEEAASS ; GMDFNYSFSY ; QLEGESRKSC ; SLHQAPTVRG ; 150: SVRFWCSLPT ; ADTSSFVPLE ; LQVTEASGSP ; RYHRIIHINE ; VVLLDAPAGL ; 200: LARRAEEGSH ; VVLRWLPPPG ; APMTTHIRYE ; VDVSAGNRAG ; GTQRVEVLEG ; 250: RTECVLSNLR ; GGTRYTFAVR ; ARMAEPSFSG ; FWSAWSEPAS ; LLTASDLDPL ; 300: ILTLSLILVL ; ISLLLTVLAL ; LSHRRTLQQK ; IWPGIPSPES ; EFEGLFTTHK ; 350: GNFQLWLLQR ; DGCLWWSPGS ; SFPEDPPAHL ; EVLSEPRWAV ; TQAGDPGADD ; 400: EGPLLEPVGS ; EHAQDTYLVL ; DKWLLPRTPC ; SENLSGPGGS ; VDPVTMDEAS ; 450: ETSSCPSDLA ; SKPRPEGTSP ; SSFEYTILDP ; SSQLLCPRAL ; PPELPPTPPH ; 500: LKYLYLVVSD ; SGISTDYSSG ; GSQGVHGDSS ; DGPYSHPYEN ; SLVPDSEPLH ; 507: PGYVACS
Sequence Length	507
String	P14753
Sub Unit	Forms homodimers on EPO stimulation. The tyrosine-phosphorylated form interacts with several SH2 domain-containing proteins including LYN, the adapter protein APS, PTPN6, PTPN11, JAK2, PI3 kinases, STAT5A/B, SOCS3 and CRKL. The N-terminal SH2 domain of PTPN6 binds Tyr-453 and inhibits signaling through dephosphorylation of JAK2. APS binding also inhibits the JAK-STAT signaling. Binding to PTPN11, preferentially through the N-terminal SH2 domain, promotes mitogenesis and phosphorylation of PTPN11. Binding of JAK2 (through its N-terminal) promotes cell-surface expression. Interaction with the ubiquitin ligase NOSIP mediates EPO-induced cell proliferation. Interacts with ATXN2L (By similarity). Forms heterooligomers with friend spleen focus-forming virus (FSFFV) gp55, probably via their respective transmembrane domains. Interacts with INPP5D/SHIP1.

Uniprot	P14753
Gene Name	Epor
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:13857
Unigene	Mm.2653

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SKU	Supplier No.	Size	Your price	Quantity
BHE13804233	E0027m	96T	$776		Add to Cart

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