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ELISA Kit for Mouse DNA-binding protein Ikaros

SKU : BHE13804866

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14258m
Alternative Names	Ikaros family zinc finger protein 1 ; Lymphoid transcription factor LyF-1 ; Ikaros ; Lyf1 ; Zfpn1a1 ; Znfn1a1
Categories	Elisa
Function	Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells (By similarity). Confers early temporal competence to retinal progenitor cells (RPCs).
Specificity	Natural and recombinant Mouse DNA-binding protein Ikaros
Subcellular Location	Isoform I Cytoplasm
Detection Range	0.156-10ng/mL
Entryname	IKZF1_MOUSE
Method Type	Sandwich
Platform	PF00096
Protein Name	DNA-binding protein Ikaros
Sensitivity	0.085ng/mL
Sequence	50: MDVDEGQDMS ; QVSGKESPPV ; SDTPDEGDEP ; MPVPEDLSTT ; SGAQQNSKSD ; 100: RGMGSNVKVE ; TQSDEENGRA ; CEMNGEECAE ; DLRMLDASGE ; KMNGSHRDQG ; 150: SSALSGVGGI ; RLPNGKLKCD ; ICGIVCIGPN ; VLMVHKRSHT ; ERPFQCNQCG ; 200: ASFTQKGNLL ; RHIKLHSGEK ; PFKCHLCNYA ; CRRRDALTGH ; LRTHSVGKPH ; 250: KCGYCGRSYK ; QRSSLEEHKE ; RCHNYLESMG ; LPGVCPVIKE ; ETNHNEMAED ; 300: LCKIGAERSL ; VLDRLASNVA ; KRKSSMPQKF ; LGDKCLSDMP ; YDSANYEKED ; 350: MMTSHVMDQA ; INNAINYLGA ; ESLRPLVQTP ; PGSSEVVPVI ; SSMYQLHKPP ; 400: SDGPPRSNHS ; AQDAVDNLLL ; LSKAKSVSSE ; REASPSNSCQ ; DSTDTESNAE ; 450: EQRSGLIYLT ; NHINPHARNG ; LALKEEQRAY ; EVLRAASENS ; QDAFRVVSTS ; 500: GEQLKVYKCE ; HCRVLFLDHV ; MYTIHMGCHG ; CHGFRDPFEC ; NMCGYHSQDR ; 517: YEFSSHITRG ; EHRYHLS
Sequence Length	517
String	Q03267
Sub Unit	Heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5 (By similarity). Component of the chromatin-remodeling NuRD repressor complex which includes at least HDAC1, HDAC2, RBBP4, RBBP7, IKZF1, MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4. Interacts directly with the CHD4 component of the NuRD complex. Component of the BAF (SWI/SNF) gene activator complex which includes ACTB, ARID1A, ARID1B, IKZF1, ARID1A, ARID1B, SMARCA2, SMARCA4 and at least one BAF subunit. Interacts directly with the SMARCA4 component of the BAF complex. Interacts with SUMO1; the interaction sumoylates IKAROS, promoted by PIAS2 and PIAS3. Interacts with PIAS2 (isoform alpha); the interaction promotes sumoylation and reduces transcription repression. Interacts, to a lesser extent, with PIAS3. Interacts with PPP1CC; the interaction targets PPP1CC to pericentromeric heterochromatin, dephosphorylates IKAROS, stabilizes it and prevents it from degradation. Interacts with IKZF3.

Uniprot	Q03267
Gene Name	Ikzf1
Immunogen Species	Mus musculus (Mouse)
Unigene	Mm.103545

Reference	1. "Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment." Georgopoulos K., Moore D.D., Derfler B. Science258:808-812(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM V);FUNCTION;DEVELOPMENTAL STAGE;TISSUE SPECIFICITY tissue: Embryo. 2. "The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene." Hahm K., Ernst P., Lo K., Kim G.S., Turck C., Smale S.T. Mol. Cell. Biol.14:7111-7123(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;ALTERNATIVE SPLICING;TISSUE SPECIFICITY 3. "Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation." Morgan B., Sun L., Avitahl N., Andrikopoulos K., Ikeda T., Gonzales E., Wu P., Neben S., Georgopoulos K. EMBO J.16:2004-2013(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IKZF3 4. "Defects in hemopoietic stem cell activity in Ikaros mutant mice." Nichogiannopoulou A., Trevisan M., Neben S., Friedrich C., Georgopoulos K. J. Exp. Med.190:1201-1214(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE 5. "Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding." Cobb B.S., Morales-Alcelay S., Kleiger G., Brown K.E., Fisher A.G., Smale S.T. Genes Dev.14:2146-2160(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-152; PHE-153; THR-154; GLN-155; LYS-156; GLY-157; ASN-158; LEU-159; LEU-160; ARG-161; LYS-173; ASN-178; TYR-179; ALA-180; CYS-181; ARG-182; ARG-183; ARG-184; ASP-185; ALA-186; LEU-187; THR-188; GLY-189; LEU-191; ARG-192 AND THR-193 6. "An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells." O'Neill D.W., Schoetz S.S., Lopez R.A., Castle M., Rabinowitz L., Shor E., Krawchuk D., Goll M.G., Renz M., Seelig H.P., Han S., Seong R.H., Park S.D., Agalioti T., Munshi N., Thanos D., Erdjument-Bromage H., Tempst P., Bank A.more... Mol. Cell. Biol.20:7572-7582(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE NURD COMPLEX;IDENTIFICATION IN THE BAF COMPLEX;INTERACTION WITH CHD4;FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY 7. "A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains." Dovat S., Ronni T., Russell D., Ferrini R., Cobb B.S., Smale S.T. Genes Dev.16:2985-2990(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-140; SER-167 AND SER-195;SUBCELLULAR LOCATION;DNA-BINDING;MUTAGENESIS OF THR-140; SER-167 AND SER-195 8. "Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition." Gomez-del Arco P., Maki K., Georgopoulos K. Mol. Cell. Biol.24:2797-2807(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-63; SER-384; SER-386; SER-388; SER-392 AND THR-393;DNA-BINDING;FUNCTION;MUTAGENESIS OF SER-63; SER-384; SER-386; SER-388; SER-392 AND THR-393 9. "Ikaros SUMOylation: switching out of repression." Gomez-del Arco P., Koipally J., Georgopoulos K. Mol. Cell. Biol.25:2688-2697(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-58 AND LYS-239;INTERACTION WITH SUMO1; PIAS2; PIAS3 AND SMARCA4;FUNCTION;MUTAGENESIS OF LYS-58; LYS-239; LYS-424 AND LYS-458 10. "Ikaros increases normal apoptosis in adult erythroid cells." Pulte D., Lopez R.A., Baker S.T., Ward M., Ritchie E., Richardson C.A., O'Neill D.W., Bank A. Am. J. Hematol.81:12-18(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 11. "Ikaros confers early temporal competence to mouse retinal progenitor cells." Elliott J., Jolicoeur C., Ramamurthy V., Cayouette M. Neuron60:26-39(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY 12. "Recruitment of ikaros to pericentromeric heterochromatin is regulated by phosphorylation." Gurel Z., Ronni T., Ho S., Kuchar J., Payne K.J., Turk C.W., Dovat S. J. Biol. Chem.283:8291-8300(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-13; THR-23; SER-63; SER-101 AND SER-293;FUNCTION;SUBCELLULAR LOCATION;DNA-BINDING;IDENTIFICATION BY MASS SPECTROMETRY;MUTAGENESIS OF SER-13; THR-23; SER-63; SER-101 AND SER-293 13. "Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1." Popescu M., Gurel Z., Ronni T., Song C., Hung K.Y., Payne K.J., Dovat S. J. Biol. Chem.284:13869-13880(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP1CC;PHOSPHORYLATION;SUBCELLULAR LOCATION;UBIQUITINATION;MUTAGENESIS OF 465-LEU--LEU-467

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