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ELISA Kit for Mouse B-cell linker protein

SKU : BHE13801735

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1600m
Alternative Names	B-cell adapter containing a SH2 domain protein ; B-cell adapter containing a Src homology 2 domain protein ; Cytoplasmic adapter protein ; Lymphocyte antigen 57 ; Src homology 2 domain-containing leukocyte protein of 65 kDa ; Slp-65 ; Bash ; Ly57 ; Slp65
Categories	Elisa
Function	Functions as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition (By similarity). Plays an important role in BCR-induced B-cell apoptosis.
Specificity	Natural and recombinant Mouse B-cell linker protein
Subcellular Location	Cytoplasm Cell membrane BCR activation results in the translocation to membrane fraction.
Detection Range	0.156-10ng/mL
Entryname	BLNK_MOUSE
Method Type	Sandwich
Platform	PF00017
Protein Name	B-cell linker protein
Sensitivity	0.08ng/mL
Sequence	50: MDKLNKITVP ; ASQKLRQLQK ; MVHDIKNNEG ; GIMDKIKKLK ; VKGPPSVPRR ; 100: DYALDSPADE ; EEQWSDDFDS ; DYENPDEHSD ; SEMYVMPAEE ; TGDDSYEPPP ; 150: AEQQTRVVHP ; ALPFTRGEYV ; DNRSSQRHSP ; PFSKTLPSKP ; SWPSAKARLA ; 200: STLPAPNSLQ ; KPQVPPKPKD ; LLEDEADYVV ; PVEDNDENYI ; HPRESSPPPA ; 250: EKAPMVNRST ; KPNSSSKHMS ; PPGTVAGRNS ; GVWDSKSSLP ; AAPSPLPRAG ; 300: KKPATPLKTT ; PVPPLPNASN ; VCEEKPVPAE ; RHRGSSHRQD ; TVQSPVFPPT ; 350: QKPVHQKPVP ; LPRFPEAGSP ; AADGPFHSFP ; FNSTFADQEA ; ELLGKPWYAG ; 400: ACDRKSAEEA ; LHRSNKDGSF ; LIRKSSGHDS ; KQPYTLVAFF ; NKRVYNIPVR ; 450: FIEATKQYAL ; GKKKNGEEYF ; GSVVEIVNSH ; QHNPLVLIDS ; QNNTKDSTRL ; 457: KYAVKVS
Sequence Length	457
String	Q9QUN3
Sub Unit	Associates with PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with VAV3, PLCG2 and GRB2 (By similarity). Interacts through its SH2 domain with CD79A.

Uniprot	Q9QUN3
Gene Name	Blnk
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:17060
Unigene	Mm.9749

Reference	1. "BLNK: a central linker protein in B cell activation." Fu C., Turck C.W., Kurosaki T., Chan A.C. Immunity9:93-103(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation." Wienands J., Schweikert J., Wollschied B., Jumaa H., Nielsen P.J., Reth M. J. Exp. Med.188:791-795(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 7-20; 147-161; 170-186; 356-366 AND 393-412;FUNCTION;TISSUE SPECIFICITY;PHOSPHORYLATION;INTERACTION WITH VAV1 AND GRB2 strain: BALB/c. tissue: Lymphoid tissue. 3. "BASH: B lymphocyte adaptor protein containing SH2 domain." Okamoto N., Hayashi K., Tsuji S., Goitsuka R., Kitamura D. Submitted (1998-06) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 4. "The murine SLP-65 gene." Nielsen P.J., Guenet J.-L. Submitted (2000-11) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: 129. tissue: Mammary tumor. 6. "Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha." Engels N., Wollscheid B., Wienands J. Eur. J. Immunol.31:2126-2134(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CD79A;MUTAGENESIS OF ARG-373 7. "Receptor-facilitated antigen presentation requires the recruitment of B cell linker protein to Igalpha." Siemasko K., Skaggs B.J., Kabak S., Williamson E., Brown B.K., Song W., Clark M.R. J. Immunol.168:2127-2138(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CD79A 8. "The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways." Kabak S., Skaggs B.J., Gold M.R., Affolter M., West K.L., Foster M.S., Siemasko K., Chan A.C., Aebersold R., Clark M.R. Mol. Cell. Biol.22:2524-2535(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CD79A 9. "Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia." Jumaa H., Bossaller L., Portugal K., Storch B., Lotz M., Flemming A., Schrappe M., Postila V., Riikonen P., Pelkonen J., Niemeyer C.M., Reth M. Nature423:452-456(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PRO-B CELL TO PRE-B CELL TRANSITION;MUTAGENESIS OF TYR-52 AND TYR-96 10. "The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development." Kulathu Y., Hobeika E., Turchinovich G., Reth M. EMBO J.27:1333-1344(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SYK ACTIVATION;INTERACTION WITH SYK;MUTAGENESIS OF ARG-373 11. "SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling." Draber P., Vonkova I., Stepanek O., Hrdinka M., Kucova M., Skopcova T., Otahal P., Angelisova P., Horejsi V., Yeung M., Weiss A., Brdicka T. Mol. Cell. Biol.31:4550-4562(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SCIMP 12. "Solution structure of the SH2 domain from mouse B-cell linker protein BLNK." RIKEN structural genomics initiative (RSGI) Submitted (2008-04) to the PDB data bank [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 328-457

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