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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Histone H2AX

SKU : BHE13805000

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15010h
Alternative Names	Histone H2A.X ; H2AX
Categories	Elisa
Function	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Specificity	Natural and recombinant Human Histone H2AX
Subcellular Location	Nucleus Chromosome
Detection Range	78-5000pg/mL
Entryname	H2AX_HUMAN
Method Type	Sandwich
Platform	PF00125
Protein Name	Histone H2AX
Sensitivity	39.7pg/mL
Sequence	50: MSGRGKTGGK ; ARAKAKSRSS ; RAGLQFPVGR ; VHRLLRKGHY ; AERVGAGAPV ; 100: YLAAVLEYLT ; AEILELAGNA ; ARDNKKTRII ; PRHLQLAIRN ; DEELNKLLGG ; 143: VTIAQGGVLP ; NIQAVLLPKK ; TSATVGPKAP ; SGGKKATQAS ; QEY
Sequence Length	143
String	P16104
Sub Unit	The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with numerous proteins required for DNA damage signaling and repair when phosphorylated on Ser-140. These include MDC1, TP53BP1, BRCA1 and the MRN complex, composed of MRE11A, RAD50, and NBN. Interaction with the MRN complex is mediated at least in part by NBN. Also interacts with DHX9/NDHII when phosphorylated on Ser-140. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation.

Uniprot	P16104
Gene Name	H2AFX
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:3014
Unigene	Hs.477879

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805000	E15010h	96T	$736		Add to Cart

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