JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Dog Podocalyxin

SKU : BHE13808940

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E0768d
Alternative Names	Gp135 ; Podocalyxin-like protein 1 ; PC ; PC-like protein 1 ; PCLP-1 ; cPCLP1 ; PCLP ; PCLP1
Categories	Elisa
Function	Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
Specificity	Natural and recombinant Dog Podocalyxin
Subcellular Location	Apical cell membrane Membrane raft Cell projection lamellipodium Cell projection filopodium Cell projection ruffle Cell projection microvillus Membrane Single-pass type I membrane protein Forms granular, punctuated pattern, forming patches, preferentially adopting a polar distribution, located on the migrating poles of the cell or forming clusters along the terminal ends of filipodia establishing contact with the endothelial cells. Colocalizes with the submembrane actin of lamellipodia, particularly associated with ruffles. Colocalizes with vinculin at protrusions of cells. Colocalizes with ITGB1. Colocalizes with actin filaments, ezrin and SLC9A3R1 in a punctate pattern at the apical cell surface where microvilli form. Colocalizes with EZR and SLC9A3R2 at the apical cell membrane of glomerular epithelium cells (By similarity). In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1 at the trans-Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, RAB11A and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis.
Entryname	PODXL_CANFA
Platform	PF06365
Protein Name	Podocalyxin
Sequence	50: MRPAPPPPLL ; LLLLLLPPPS ; LSHDGTIIAA ; TSPTSGQPST ; ELPGGKGLIT ; 100: TAKTIQNTDL ; AITGEKVMSA ; TVSKGPLPGS ; SNSVSMTLAP ; TQKNTVIAPD ; 150: QDEKVSTNPT ; IATSDSKGIP ; DLNKSILPSA ; TNSMKPDTPV ; TQTAGPGAQG ; 200: NPGTTVSHMT ; SENTEQTTSQ ; PPPQVKPSSI ; TPALTSIITP ; TSPRQPSANS ; 250: TTLKPPESSS ; ESPDKSHTAS ; SSLGTKVVPS ; SSLYGTSPTR ; TSSVTFWGGP ; 300: QSSSGTPPVP ; APTPRPAATS ; SSTPGISSVP ; GTTSLPSETE ; SLESPSSESP ; 350: SQPPKLRPTG ; PPSSGSSGPA ; ASLPDEGPRS ; SSTQRAATAP ; RAPSVPSPTS ; 400: AQGDDRIKCE ; SPGRLTDKML ; LLNLTRSGLC ; AGNNSDDKLI ; TLLCRAAKAT ; 450: FNPAQDQCHI ; RLVPIQDTQA ; VAIKEITVQT ; NLLPRDVYEL ; LKDKWDELKE ; 500: VGVSNMKLGD ; QGPPEETEDR ; FSMPLIITIV ; CMASFLLLVA ; ALYGCCHQRL ; 550: SQRKDQQRLT ; EELQTVENGY ; HDNPTLEVME ; TSSEMQEKKV ; VNLNGELGDS ; 571: WIVPLDNLAK ; DDLDEEEDTH ; L
Sequence Length	571
String	Q52S86
Sub Unit	Found in a complex with EZR, PODXL and SLC9A3R2. Associates with the actin cytoskeleton through complex formation with EZR and SLC9A3R2. Interacts (via the C-terminal PDZ-binding motif DTHL) with SLC9A3R1 (via the PDZ domains); interaction is not detected in glomerular epithelium cells. Interacts (via the C-terminal PDZ-binding motif DTHL) with SLC9A3R2 (via the PDZ 1 domain); interaction is detected in glomerular epithelium cells. Interacts with EZR (By similarity). Monomer; when associated with the membrane raft. Oligomer; when integrated in the apical membrane. Interacts with SLC9A3R2. Interacts (via the C-terminal PDZ-binding motif DTHL) with SLC9A3R1 (via the PDZ domains); the interaction take place early in the secretory pathway and is necessary for its apical membrane sorting.

Uniprot	Q52S86
Gene Name	PODXL
Immunogen Species	Canis Lupus Familiaris (Dog)
Kegg	cfa:482252
Unigene	Cfa.23488

Reference	1. "Molecular identification of canine podocalyxin-like protein 1 as a renal tubulogenic regulator." Cheng H.Y., Lin Y.Y., Yu C.Y., Chen J.Y., Shen K.F., Lin W.L., Liao H.K., Chen Y.J., Liu C.H., Pang V.F., Jou T.S. J. Am. Soc. Nephrol.16:1612-1622(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 398-406; 448-466 AND 525-538;FUNCTION;SUBCELLULAR LOCATION;GLYCOSYLATION AT ASN-199; ASN-373 AND ASN-383;MUTAGENESIS OF ASN-123; ASN-199; ASN-373 AND ASN-383;TISSUE SPECIFICITY 2. "Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells." Meder D., Shevchenko A., Simons K., Fuellekrug J. J. Cell Biol.168:303-313(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SLC9A3R2;SUBCELLULAR LOCATION 3. "A bipartite signal regulates the faithful delivery of apical domain marker podocalyxin/Gp135." Yu C.Y., Chen J.Y., Lin Y.Y., Shen K.F., Lin W.L., Chien C.L., ter Beest M.B., Jou T.S. Mol. Biol. Cell18:1710-1722(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;INTERACTION WITH SLC9A3R1;GLYCOSYLATION AT ASN-199; ASN-373 AND ASN-383;MUTAGENESIS OF ASN-199; ASN-373 AND ASN-383

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13808940	E0768d	96T	$900		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.