The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
Host
Rabbit
Immunogen
RAB27A, member RAS oncogene family
Isotype
IgG
Molecular Weight
27 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Synonyms
RAB27
Uniprot
P51159
Gene Id
5873
Research Area
Signal Transduction, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)