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Home / Antibodies

POMC Antibody

SKU : BHA10553890

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA914135
Alternative Names	proopiomelanocortin
Antigen	POMC
Categories	Primary Antibodies
Conjugate	Non-conjugated
Description	This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation.
Host	Rabbit
Immunogen	Synthetic peptide of human POMC（Beta endorphin）
Involvement In Disease	Obesity (OBESITY); Pro-opiomelanocortinin deficiency (POMCD)
Isotype	IgG
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation.
Species	Homo Sapiens (Human)
Subcellular Location	Secreted

Uniprot	P01189
Gene Id	5443
Database Links	HGNC:9201 OMIM:176830 KEGG:hsa:5443 STRING:9606.ENSP00000264708 UniGene:Hs.1897
Function	Corticotropin
Pathway	Melanogenesis Adipocytokine signaling pathway
Protein Families	POMC family
Tissue Specificity	ACTH and MSH are produced by the pituitary gland.
Weight	ACTH is ~5kDa; the POMC precursor is ~30kDa.

Buffer	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form	Liquid
Format	Liquid
Purification	Antigen affinity purification
Purity	Antigen affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

ELISA	1:2000-1:5000
WB	1:500-1:2000

Tested Application

ELISA,WB;ELISA:1:2000-1:5000,WB:1:500-1:2000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10553890	CSB-PA914135	100μl	$279.30		Add to Cart
BHA10553890	CSB-PA914135	50μl	$168		Add to Cart

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