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Home / Antibodies

Phospho-CDK1/CDC2 (Thr161) Antibody

SKU : BHA12907973

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AFFINITY BIOSCIENCES LTD

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Mfr.No.	AF8001
Alternative Names	Cdc 2 ; Cdc2 ; CDC28A ; CDK 1 ; CDK1 ; CDK1_HUMAN ; CDKN1 ; CELL CYCLE CONTROLLER CDC2 ; Cell division control protein 2 ; Cell division control protein 2 homolog ; Cell division cycle 2 G1 to S and G2 to M ; Cell division protein kinase 1 ; Cell Divsion Cycle 2 Protein ; Cyclin Dependent Kinase 1 ; Cyclin-dependent kinase 1 ; DKFZp686L20222 ; MGC111195 ; p34 Cdk1 ; p34 protein kinase ; P34CDC2 ;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation
Immunogen	The antiserum was produced against synthesized phosphopeptide derived from human CDC2 around the phosphorylation site of Threonine161.
Molecular Weight	Observed Mol.Wt.: 34KD. Predicted Mol.Wt.: 35kDa.
Reactivity	Human, Mouse, Rat
Specificity	CDC2(Phospho-Thr161) Antibody detects endogenous levels of CDC2 only when phosphorylated at Threonine 161.
Subcellular Location	Nucleus.

Uniprot

P06493

Gene Id

983

Sequence

10	20	30	40	50
MEDYTKIEKI	GEGTYGVVYK	GRHKTTGQVV	AMKKIRLESE	EEGVPSTAIR
60	70	80	90	100
EISLLKELRH	PNIVSLQDVL	MQDSRLYLIF	EFLSMDLKKY	LDSIPPGQYM
110	120	130	140	150
DSSLVKSYLY	QILQGIVFCH	SRRVLHRDLK	PQNLLIDDKG	TIKLADFGLA
160	170	180	190	200
RAFGIPIRVY	THEVVTLWYR	SPEVLLGSAR	YSTPVDIWSI	GTIFAELATK
210	220	230	240	250
KPLFHGDSEI	DQLFRIFRAL	GTPNNEVWPE	VESLQDYKNT	FPKWKPGSLA
260	270	280	290
SHVKNLDENG	LDLLSKMLIY	DPAKRISGKM	ALNHPYFNDL	DNQIKKM

Concentration	1mg/ml
Format	Liquid
Purification	The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Storage Condition	PBS, pH 7.4,50% glycerol.

Applications	IF/ICC, ELISA, IHC, WB
Dilution	WB 1:1000 IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Manual
MSDS
IHC Protocol.
Western Blotting Handbook.

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SKU	Supplier No.	Size	Your price	Quantity
BHA12907973	AF8001	100ul	$350		Add to Cart
BHA12907973	AF8001	200ul	$450		Add to Cart

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