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Home / Primary Antibodies / Polyclonal Antibodies

NRF2, NFE2L2 antibody

SKU : BHA10805847

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Mfr.No.	FNab05855
Background	NRF2, also named as NFE2L2, belongs to the bZIP family and CNC subfamily. It is a transcription activator that binds to antioxidant response(ARE) elements in the promoter regions of target genes. NRF2 is important for the coordinated up-regulation of genes in response to oxidative stress. It may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.Nrf2 is a key player in the regulation of genes encoding for many antioxidative response enzymes.The expression of NRF2 may be induced under oxidative stress(PMID:14567983).In lung cancer, Nrf2 activation in malignant cells has been associated with tumor progression and chemotherapy resistance(PMID:20534738). Identifying patients with abnormal NRF2 expression may be important for selection for chemotherapy in NSCLC.
Categories	Primary Antibodies
Clonality	polyclonal
Host	Rabbit
Immunogen	nuclear factor(erythroid-derived 2)-like 2
Isotype	IgG
Molecular Weight	70-100 kDa
Reactivity	Human, Mouse, Rat, Zebrafish
Regulatory	RUO
Synonyms	HEBP1, NF E2 related factor 2, NFE2 related factor 2, NFE2L2, NRF2

Uniprot	Q16236
Gene Id	4780
Research Area	Epigenetics, Developmental biology, Cancer, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IP, WB, IHC, FC
Description	ELISA ; IP ; WB ; IHC ; FC
Tested Application	WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:50-1:500

Manual	FNab05855.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805847	FNab05855	100ug	$260		Add to Cart

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