This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism in this gene is associated with the onset of Parkinson's disease. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.
Categories
Primary Antibodies
Clonality
polyclonal
Description
IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.
Host
Rabbit
Immunogen
mitochondrial translational initiation factor 3
Isotype
IgG
Molecular Weight
32 kDa
Reactivity
Human, Rat
Regulatory
RUO
Synonyms
IF3mt
Uniprot
Q9H2K0
Gene Id
219402
Research Area
Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)