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Home / Primary Antibodies / Polyclonal Antibodies

MMP13 antibody

SKU : BHA10805227

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Mfr.No.	FNab05235
Background	Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.It can detect the glycosylated proMMP-13(70 kDa), unglycosylated proform(54 kDa).
Categories	Primary Antibodies
Clonality	polyclonal
Description	Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
Host	Rabbit
Immunogen	matrix metallopeptidase 13(collagenase 3)
Isotype	IgG
Molecular Weight	54kd,70kd
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	CLG3, Collagenase 3, Matrix metalloproteinase 13, MMP 13, MMP13

Uniprot	P45452
Gene Id	4322
Research Area	Stem Cells, Cardiovascular, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, WB, IF
Description	ELISA ; IHC ; WB ; IF
Tested Application	WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100

Manual	FNab05235.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805227	FNab05235	100ug	$240		Add to Cart

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