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Home / Primary Antibodies / Polyclonal Antibodies

LGR5 antibody

SKU : BHA10804757

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Mfr.No.	FNab04765
Alternative Names	GPR49 ; GPR67
Background	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins(RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R- spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
Host	Rabbit
Immunogen	leucine-rich repeat-containing G protein-coupled receptor 5
Isotype	IgG
Molecular Weight	92-120kd
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	FEX, G protein coupled receptor 49, G protein coupled receptor 67, GPR49, GPR67, GRP49, HG38, LGR5

Uniprot	O75473
Gene Id	8549
Research Area	Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC
Description	ELISA ; IHC
Tested Application	WB: 1:500-1:2000; IHC: 1:100-1:400

Manual	FNab04765.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804757	FNab04765	100ug	$280		Add to Cart

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