The protein encoded by this gene functions to recycle protein-bound biotin by cleaving biocytin (biotin-epsilon-lysine), a normal product of carboxylase degradation, resulting in regeneration of free biotin. The encoded protein has also been shown to have biotinyl transferase activity. Mutations in this gene are associated with biotinidase deficiency. Multiple transcript variants encoding different isoforms have been described.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.
Host
Rabbit
Immunogen
biotinidase
Isotype
IgG
Molecular Weight
60 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Uniprot
P43251
Gene Id
686
Research Area
Metabolism, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)