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Home / Primary Antibodies / Polyclonal Antibodies

BMP2 antibody

SKU : BHA10800912

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Mfr.No.	FNab00917
Alternative Names	BMP2A
Background	Bone morphogenetic protein-2 (BMP-2) is a member of the transforming growth factor-beta (TGFB) superfamily. BMP2 is synthesized as a 60 kDa precursor that is processed in the secretory pathway to a small 18 kDa monomer; 2 monomers then associate to form the active 30 kDa homodimer, which binds to its receptor. There is also a 40-45 kDa form of BMP2, as an amino-terminal propeptide. BMP2 can induce bone formation and regeneration during early embryonic development. It is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
Host	Rabbit
Immunogen	bone morphogenetic protein 2
Isotype	IgG
Molecular Weight	45 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	BMP2A

Uniprot	P12643
Gene Id	650
Research Area	Developmental biology, Stem Cells

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:500-1: 5000
IHC	1:20-1:200
IF	1:50-1:500

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

Manual	FNab00917.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800912	FNab00917	100ug	$240		Add to Cart

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