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Home / Primary Antibodies / IHC Antibodies

Anti-RAE1 Antibody BHA11308238

SKU : BHA11308238

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Mfr.No.	BS8377
Alternative Names	mRNA export factor ; Rae1 protein homolog ; mRNA-associated protein mrnp 41 ; RAE1 ; MRNP41
Antigen	RAE1
Categories	Primary Antibodies
Chromosome Location	20q13.31
Clonality	polyclonal
Description	Natural killer (NK) cells attack tumor and infected cells, but the receptors and ligands that stimulate them are poorly understood. Two murine ligands for the lectin-like receptor NKG2D, H60 and retinoic acid early inducible (Rae- 1α, β, γ, δ and ε), are distant relatives of major histocompatibility complex class I molecules. These molecules are encoded by Rae-1 and H60 minor histocompatibility antigen genes on mouse chromosome 10 and show weak homology with MHC class I. Expression of the NKG2D ligands is low or absent on normal, adult tissues; however, they are constitutively expressed on some tumors and upregulated by retinoic acid. Ectopic expression of Rae-1 and H60 confers target susceptibility to NK cell attack. NKG2D binds to H60 with approximately 25-fold higher affinity than to Rae-1. Rae-1 and H60 compete directly for occupancy of NKG2D; therefore, NKG2D can be occupied by only one ligand at a time. Additionally, Rae-1 and H60 ligands of the NKG2D receptor stimulate tumor immunity.
Host	Rabbit
Immunogen	Recombinant full length Human RAE1.
Reactivity	Human, Mouse, Rat
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P78406
Uniprot	P78406
Weight	41 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: RAE1 polyclonal antibody detects endogenous levels of RAE1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC, IF

Description

WB ; IHC ; IF

Dilution

WB	1:500-1:2000
IHC/IF	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11308238	BS8377	50µl	$234.89		Add to Cart
BHA11308238	BS8377	100µl	$368.22		Add to Cart

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