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Home / Primary Antibodies / Recombinant Antibodies

Anti-PTEN Antibody BHA11304828

SKU : BHA11304828

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Mfr.No.	BS6493
Alternative Names	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN ; Mutated in multiple advanced cancers 1 ; Phosphatase and tensin homolog ; PTEN ; MMAC1 ; TEP1
Antigen	PTEN
Categories	Primary Antibodies
Clonality	polyclonal
Description	As human tumors progress to advanced stages, one genetic alteration that occurs at high frequency is a loss of heterozygosity (LOH) at chromosome 10q23. Mapping of homozygous deletions on this chromosome led to the isolation of the PTEN gene, also designated MMAC1 (for mutated in multiple advanced cancers) and TEP1. This candidate tumor suppressor gene exhibits a high frequency of mutations in human glioblastomas and is also mutated in other cancers, including sporadic brain, breast, kidney and prostate cancers. PTEN has been associated with Cowden disease, an autosomal dominant cancer predisposition syndrome. The PTEN gene product is a putative protein tyrosine phosphatase that is localized to the cytoplasm, and it shares extensive homology with the cytoskeletal proteins tensin and auxilin. Gene transfer studies have indicated that the phosphatase domain of PTEN is essential for growth suppression of glioma cells.
Host	Rabbit
Immunogen	Recombinant full length Human PTEN.
Reactivity	Human, Mouse
Recombinant	TRUE
Regulatory	RUO

Swissprot	P60484
Uniprot	P60484
Weight	47, 54 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: PTEN polyclonal antibody detects endogenous levels of PTEN protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304828	BS6493	50µl	$234.89		Add to Cart
BHA11304828	BS6493	100µl	$368.22		Add to Cart

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