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Home / Primary Antibodies / Recombinant Antibodies

Anti-HAS3 Antibody BHA11308179

SKU : BHA11308179

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Mfr.No.	BS8298
Alternative Names	Hyaluronan synthase 3 ; Hyaluronate synthase 3 ; Hyaluronic acid synthase 3 ; HA synthase 3 ; HAS3
Antigen	HAS3
Categories	Primary Antibodies
Chromosome Location	16q22.1
Clonality	polyclonal
Description	HAS1, HAS2 and HAS3 are HA (hyaluronan or hyaluronic acid) synthase proteins. The extracellular matrix in most vertebrates express HA, which is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by b-1,3 and b-1,4 glycosidic bonds. The three HAS genes show distinct patterns of expression during development and their protein products play significantly different roles in the formation of the HA matrix. Both HAS1 and HAS2 synthesize high molecular-weight HA, whereas HAS3 produces lower molecular weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regulated by various stimuli, suggesting distinct functional roles of the three proteins. HAS3 produces both secreted and cell-associated forms of hyaluronan and is the most active of the three isoforms of this enzyme in adults. HAS3 gene expression plays a crucial role in the regulation of hyaluronan synthesis in the epidermis. Specifically, IFN-g markedly upregulates HAS3 mRNA, whereas TGFβ downregulates HAS3 transcript levels. The human HAS3 gene maps to chromosome 16q22.1.
Host	Rabbit
Immunogen	Recombinant full length Human HAS3.
Reactivity	Human, Mouse, Rat
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	O00219
Uniprot	O00219
Weight	63 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: HAS3 polyclonal antibody detects endogenous levels of HAS3 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC, IF

Description

WB ; IHC ; IF

Dilution

WB	1:500-1:2000
IHC	1:50-1:200
IF	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11308179	BS8298	50µl	$234.89		Add to Cart
BHA11308179	BS8298	100µl	$368.22		Add to Cart

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