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Home / Primary Antibodies / IHC Antibodies

Anti-GAD2 Antibody BHA11303853

SKU : BHA11303853

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Mfr.No.	BS6074
Alternative Names	Glutamate decarboxylase 2 ; 65 kDa glutamic acid decarboxylase ; GAD 65 ; Glutamate decarboxylase 65 kDa isoform ; GAD2 ; GAD-65 ; GAD 2 ; GAD-2
Antigen	GAD2
Categories	Primary Antibodies
Chromosome Location	10p12.1
Clonality	polyclonal
Description	There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD-65 (also known as GAD2) and GAD-67 (also known as GAD1, GAD or SCP). GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal.
Host	Rabbit
Immunogen	Recombinant full length Human GAD2.
Reactivity	Human, Mouse, Rat
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q05329
Uniprot	Q05329
Weight	65 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: GAD2 polyclonal antibody detects endogenous levels of GAD2 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC, IF

Description

WB ; IHC ; IF

Dilution

WB	1:500-1:2000
IHC	1:50-1:200
IF	1:10-1:100

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303853	BS6074	50µl	$234.89		Add to Cart
BHA11303853	BS6074	100µl	$368.22		Add to Cart

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