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Home / Antibodies

ACVR2A Antibody

SKU : BHA10551335

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA110386
Alternative Names	Activin A receptor, type IIA
Antigen	ACVR2A
Categories	Primary Antibodies
Conjugate	Non-conjugated
Description	This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
Host	Rabbit
Immunogen	Fusion protein of Human ACVR2A
Isotype	IgG
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
Species	Homo Sapiens (Human)
Subcellular Location	Membrane, Single-pass type I membrane protein

Uniprot	P27037
Gene Id	92
Database Links	HGNC:173 OMIM:102581 KEGG:hsa:92 STRING:9606.ENSP00000241416 UniGene:Hs.470174
Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).
Pathway	TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells
Protein Families	Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
Weight	45,713 Da

Buffer	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form	Liquid
Format	Liquid
Purification	Antigen affinity purification
Purity	Antigen affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

ELISA	1:2000-1:5000
WB	1:500-1:2000

Tested Application

ELISA,WB;ELISA:1:2000-1:5000,WB:1:500-1:2000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10551335	CSB-PA110386	100μl	$279.30		Add to Cart
BHA10551335	CSB-PA110386	50μl	$168		Add to Cart

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