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Reactivity: Rat; Mouse; Human
Application: WB; IF; IHC
Categories: Primary Antibodies
Immunogen: A synthetic peptide of human APP
Quantity: 100µg 87kDa
Shipping Condition: Ice Packs
Storage Condition: -20C
Description: Amyloid Î² (AÎ²) precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms (1). The amino acid sequence of APP contains the amyloid domain (AÎ²), which can be released by a two-step proteolytic cleavage (1). The extracellular deposition and accumulation of the released AÎ² fragments form the main components of amyloid plaques in Alzheimer's disease (1). APP can be phosphorylated at several sites, which may affect the proteolytic processing and secretion of this protein (2-5). Phosphorylation at Thr668 (at a position corresponding to the APP695 isoform) by cyclin-dependent kinase is cell cycle-dependent and peaks during G2/M-phase (4). APP phosphorylated at Thr668 exists in adult rat brain and correlates with cultured neuronal differentiation (5,6).
Storage: Store at -20℃ (regular) and -80℃ (long term). Avoid freeze / thaw cycles.
Buffer: Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purity: Affinity purification
Desc: Specificity: Western blot analysis of extracts of various cell lines, using APP antibody.
ApplicationsApps: WB; IF; IHC
Desc: WB 1:500-1:2000IHC 1:50-1:200IF 1:10-1:100