Syno®-Synthetic DNA Libraries

Syno®-Synthetic DNA Libraries

Synbio Tech

Synbio Technologies is equipped with the world leading Syno® DNA technology platforms ranged from standard gene synthesis to the proprietary next generation Syno® 3.0 synthesis technology. We are capable of generating high quality DNA libraries of any size and complexity with an efficient timeframe and lower cost. Our synthetic DNA libraries can facilitate your various research interests: spanning from functional genetics to directed evolution, especially to protein engineering and antibody studies. In addition, Synbio Technologies’ experienced bioinformatics team can help to analyze and provide synthetic DNA libraries design to your researches.

Syno®3.0-Oligo Pool Synthesis

Syno®3.0-Oligo Pool Synthesis

Synbio Tech

Our innovative Syno® 3.0 process allows us to offer the highest quality DNA fragments,de novo synthesized genes, pathways, genomes and variant libraries at the lowest price in the industry. The breadth of our product portfolio runs from short linear ssDNA fragments to long, sequence-perfect, clonal genes and genomes in any vector of choice.

Syno®2.0-Gene Synthesis

Syno®2.0-Gene Synthesis

Synbio Tech

Syno® 2.0 platform of Synbio Tech. is an industrializedde novo DNA synthesis platform. In Syno® 2.0, our commitment is to translate the advanced DNA engineering technologies into reliable and cost-effective biological solutions. Our team has accumulated many advanced techniques that include large DNA fragments assembling (up to 150 Kb), manipulating toxic or unstable DNA fragments in a variety range of cell systems (for example: E. coli; Yeast; insect cell; mammalian cell, etc.). We offer services that include de novo gene/pathway/genome synthesis, DNA engineering, mutagenesis, DNA cloning and sub-cloning, PCR-cloning, plasmid DNA preparation, etc.. Our  innovative manufacturing process allows us to offer the highest quality DNA with the fastest turnaround time in the industry.

Syno®1.0-Oligo Synthesis

Syno®1.0-Oligo Synthesis

Synbio Tech

Syno® 1.0 platform of Synbio Tech. is an industrialized DNA chemical synthesis platform. Our innovative manufacturing process allows us to offer the highest quality oligos, labeled/modified oligos, degenerated oligo library, aptamers at the lowest price in the industry. The breadth of our service & product portfolio runs from short oligos to dsDNA fragments. 

Pathway design

Pathway design

Synbio Tech

Synthetic biology is a new interdisciplinary area of life science that refers to:

Metagenome Sequencing

Metagenome Sequencing

Synbio Tech

Metagenome is the study of the genome of the entire microbial community in a specific environmental sample. This is achieved by directly extracting the DNA of an environmental sample for high-throughput sequencing without isolation and culture. Metagenomic sequencing promotes research focusing on the macroscopic characteristics of microbial community structure, community diversity, species classification, functional activity, mutual cooperation and their relationship with the environment. Using this approach scientists can analyze the genetic composition and function of environmental micro-population, interpret the diversity and abundance of micro-populations, and explore the relationship between microorganism and environment, microorganism and hosts. It can more accurately reflect the actual living conditions of microorganisms.

Eukaryotic RNA sequencing

Eukaryotic RNA sequencing

Synbio Tech

Eukaryotic RNA sequencing is based on Next Generation Sequencing (NGS) and provides comprehensive and rapid access to all transcript sets of a particular cell or tissue in certain state. It is used to study gene structure and function, alternative splicing and prediction of new transcript, etc. Eukaryotic RNA sequencing can be divided into reference transcriptome and non-reference transcriptome according to with or without reference genomes.

Prokaryotic RNA sequencing

Prokaryotic RNA sequencing

Synbio Tech

Prokaryotic RNA sequencing is based on Next Generation Sequencing (NGS) platform to get all transcript information about prokaryotes at a certain time or environmental conditions by building a strand-specific RNA-seq library to sequence prokaryotic transcripts (mRNA and non-coding RNA). All sequence information of prokaryotes is obtained from gene sequence level and expression level in a specific situation. Through NGS, mRNA expression can be quantitatively analyzed, differentially express genes and their corresponding functional analysis, and also Non-coding RNAs (sRNAs) information can be figured out. Through the prediction of sRNAs target genes and the analysis of co-expression, the sRNAs corresponding function was clear, the molecular regulation mechanism and function of different phenotypes of microorganisms were revealed.

16S rDNA Sequencing

16S rDNA Sequencing

Synbio Tech

16S rDNA is a genetic sequence that encodes the 16S rRNA which is present all bacterial chromosomal genes. 16S rDNA is recognized by bacteriologists and taxonomists due to its moderate size of about 1.5 Kb. This size allows these scientists to determine the differences between different bacteria as well as easily determine the sequence through DNA sequencing. With these characteristics 16S rDNA sequencing can be used to detect a species’ classification, abundance, population structure, system evolution, and colony community of bacteria in environmental samples.

NGS High Throughput Sequencing

NGS High Throughput Sequencing

Synbio Tech

Synbio Technologies provides a wide range of second-generation sequencing services to comply with our customers’ specific requests. These services include capture chip preparation, library preparation, sample validation, as well as sequencing and bioinformatics analysis.

Long RNA Synthesis

Long RNA Synthesis

Synbio Tech

With the rapid development of the technologies related to gene editing, gene structure and function, the demand for long RNA synthesis has increased. One of the most common RNA synthesis requests is for long-stranded non-coding RNA (lncRNA), a non-coding RNA sequence with more than 200 nucleotides. These lncRNA play an important role in X-chromosome silencing, chromosome and genome modification, transcriptional activation, transcriptional interference, and intranuclear transport. The complex and precise regulatory functions of lncRNA in development and gene expression greatly contributes to the complexity of genome. lncRNA also offer researchers a fresh perspective to better understand the complexity of biological life from the dimension of gene expression regulatory network.

miRNA Synthesis

miRNA Synthesis

Synbio Tech

miRNAs are single stranded small non-coding RNA of 22 nucleotides that play important roles as endogenous gene regulators by mediating translation repression or promoting degradation of target mRNA. While the normal expression and function of miRNAs are vital for physiological processes, aberrant expression of miRNAs has been proved to be closely related to the occurrence of various cancers. Perturbation of endogeneous miRNAs helps to study the function of specific miRNAs and holds the potential for therapeutics.

Synthetic DNA Libraries Case Studies

Synthetic DNA Libraries Case Studies

Synbio Tech

Synbio Technologies’ synthetic DNA library services offer an efficient and effective method for protein engineering and directed evolution research. We are capable of designing and constructing a wide range of synthetic DNA libraries such as alanine scan library, site saturation library, random substitution library, modular substitution library to satisfy the requirements of experimenters. Synbio Technologies has extensive experience with designing and generating these libraries which has allowed us to supply our customers with high-quality synthetic DNA libraries all over the world.

Digital information storage

Digital information storage

Synbio Tech

DNA storage (using DNA as data carrier) technology is a technology that focuses in the future with epoch-making significance. It employs the four “A”, “G”, “T”, “C” bases of the DNA in a specific order arrangement to form the information coding. As a technology that can store text, images, audios and videos by using artificial synthesized DNA as the storage medium, and then fully read the data subsequently.

Your IP, Our DNA

Your IP, Our DNA

Synbio Tech

Synbio Technologies has launched the world’s first DNA Solution to protect our customers’ proprietary information within a sequence of DNA. To accomplish this DNA encryption technology, Synbio Technologies utilizes our patented DNA StudioTM which accurately synthesizes a tailor-made sequence that acts as an exclusive DNA “security code”. By utilizing our Syno® Synthesis Platforms this unique sequence, or “security code”, can be constructed into any position of the DNA. This allows the security information to be synthesized and stored as biological “water marker”.

CRISPR-Cas9 sgRNA Library

CRISPR-Cas9 sgRNA Library

Synbio Tech

CRISPR-Cas9/gRNA (CRISPR-Cas RNA-Guided nuclease) is considered as the biggest breakthrough in genome editing technology after TALEN and ZFN. It precisely edits DNA through the RNA-directed Cas9 nuclease. Previous studies indicated that the on-target gene knockout rates were higher than that with TALEN and ZFN. Besides, the construction of sgRNA-Cas9 is easier and more convenient. It has been widely applied to animal and plant breeding, directed evolution, and the site-specific restoration of genetic diseases. Synbio Technologies offers the designing, construction and validation of CRISPR-Cas9 gene target system through our patent pending platform in a highly cost and time-effective approach. We offer a one-stop solution for CRISPR Cas9 projects, including genome-scale gene targeting.

Chip Based DNA Synthesis

Chip Based DNA Synthesis

Synbio Tech

Syno®3.0 synthetic platform is a chip based DNA synthetic platform. With help of precise electrochemical technology, we can synthesize tens or even hundreds of thousands primers for one-time on a semiconductor chip.

Gene Synthesis Case Studies

Gene Synthesis Case Studies

Synbio Tech

Standard gene synthesis protocols lose fidelity when dealing with certain features such as high GC content, hairpins, and repetitive sequences. Synbio Technologies’ new NGTM Codon system (patent pending) provides a robust and sophisticated gene synthesis methods through its comprehensive codon optimization algorithm and the unique Syno® gene synthesis platform.

Syno® Gene Fragment Services

Syno® Gene Fragment Services

Synbio Tech

Synbio Technologies supplies our customers with double-stranded, sequence-verified Syno® Gene Fragments in only a few business days. These fragments offer an affordable and accessible construction or modifications of genetic sequences. The various applications include antibody research and CRISPR-mediated gene/genome editing, being used as qPCR standards, etc. Syno® Gene Fragments are available in two delivery forms: Eppendorf tubes or plates.

Vector Construction

Vector Construction

Synbio Tech

Based on our Syno®2.0 and Syno®3.0 synthesis platforms, Synbio Technologies will deliver any synthetic vector with high accuracy and economical price, especially those for research in shRNA, TALENT and CRISPR-Cas9 projects.