Anti-Cyclophilin B Monoclonal Antibody (7B2), HRP Conjugated

by abbkine
$147.78
SKU BHA13700127-50μl
Mfr.No.: A01130HRP

Antigen: Cyclophilin B

Alternative: PPIB; CYPB; Peptidyl-prolyl cis-trans isomerase B; PPIase B; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP

Reactivity: Human; Mouse; Rat

Host: Mouse(Mu)

Conjugate: HRP

Clonality: Monoclonal

Isotype: IgG

Tag: Cyclophilin B

Accession: P23284

Categories: Primary Antibodies; Control Antibodies

Description: Featured Anti-Cyclophilin B Monoclonal Antibody (7B2), HRP Conjugated, specially designed for your Western blot analysis.

Formulation: Liquid solution

Gene Id: 5479

Immunogen: Synthetic Peptide

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen

Shipping: Gel pack with blue ice.

Storage Buffer: Liquid in PBS, pH 7.4 and 50% Glycerol.

Background: Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.

Precautions: The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Storage Instructions: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Applications
Apps: IHC-P; WB

Dilution: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:1000-1:2000), IHC-P (1:50-1:300).
Protocols
Datasheet:
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