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Anti-Cyclophilin B Monoclonal Antibody (7B2), Cy3 Conjugated
Antigen: Cyclophilin B
Alternative: PPIB; CYPB; Peptidyl-prolyl cis-trans isomerase B; PPIase B; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP
Reactivity: Human; Mouse; Rat
Tag: Cyclophilin B
Categories: Primary Antibodies; Control Antibodies
Description: Featured Anti-Cyclophilin B Monoclonal Antibody (7B2), Cy3 Conjugated specially designed for your Immunofluorescence analysis.
Formulation: Liquid solution
Gene Id: 5479
Immunogen: Synthetic Peptide
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen
Shipping: Gel pack with blue ice.
Storage Buffer: Liquid in PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol.
Background: Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.
Precautions: The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Storage Instructions: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Store in the dark.
ApplicationsApps: IHC-P; IF
Dilution: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:50-1:300), IF (1:50-1:200).