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Home / Primary Antibodies / Phospho Antibodies

Anti-DAB1 Antibody BHA11302595

SKU : BHA11302595

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Mfr.No.	BS4643
Alternative Names	Disabled homolog 1 ; DAB1
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	1p32.2
Clonality	polyclonal
Description	Dab1, a homolog of the Drosophila Disabled protein, is an adaptor protein involved in neural development. This cytoplasmic protein is tyrosine-phosphorylated during rapid expansion of the developing nervous system, and it is thought to interact with other proteins via a domain similar to the PTB domains of the Shc family. Dab1 has been shown to interact with the SH2 domains of Src, Fyn and Abl. Mutations in Dab1 result in widespread abnormalities in the brain, similar to those seen in Reelin mutants. Reelin is a secreted protein thought to play a role in directing migrating neurons. Evidence suggests that Dab1 functions downstream of Reelin in a signaling pathway involved in positioning cells in the developing brain
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human Dab1 around the phosphorylation site of Tyrosine 232.
Modification	phospho-Y232
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	O75553
Uniprot	O75553
Weight	60 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-Dab1 (Y232) polyclonal antibody detects endogenous levels of Dab1 protein when phosphorylated at Tyr232
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302595	BS4643	50µl	$199.33		Add to Cart
BHA11302595	BS4643	100µl	$314.89		Add to Cart

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